{"id":"W4401084082","doi":"10.1021/acsomega.3c09817","title":"Actively Targeting Redox-Responsive Multifunctional Micelles for Synergistic Chemotherapy of Cancer","year":2024,"lang":"en","type":"article","venue":"ACS Omega","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Taiwan Instrument Research Institute, National Applied Research Laboratories; Debre Markos University; Addis Ababa University; National Taiwan University; Bahir Dar University; National Science and Technology Council; Tri-Service General Hospital; University of Waterloo; National Taiwan University of Science and Technology; National Applied Research Laboratories","keywords":"Micelle; PLGA; Ethylene glycol; Zeta potential; Chemistry; Redox; Nanocarriers; PEG ratio; Doxorubicin; Biophysics; Drug delivery; Chemosensitizer; Combinatorial chemistry; Aqueous solution; Nanoparticle; Materials science; Nanotechnology; Organic chemistry; Biochemistry; Cytotoxicity; Chemotherapy; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603908,0.0004024202,0.0001929484,0.0001484013,0.00006250798,0.0002072413,0.0001965627,0.000317379,0.0006657249],"category_scores_gemma":[0.00009454994,0.0001732079,0.0001662313,0.00009049441,0.0001174481,0.0002469918,0.0002418537,0.0003222371,0.0003044353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002290018,"about_ca_system_score_gemma":0.000152351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000176578,"about_ca_topic_score_gemma":0.0003788392,"domain_scores_codex":[0.9999183,0.00001584861,0.000006210003,0.00002085152,0.00002188618,0.00001679649],"domain_scores_gemma":[0.9999696,0.000004254129,0.00001032858,0.000002326038,0.000006350971,0.000007079098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002772156,0.00001057831,0.00001624962,0.00002372632,0.000002805605,0.00001635001,0.000006692329,0.0001225898,0.9980776,0.00007231101,0.00004102677,0.001582266],"study_design_scores_gemma":[0.00002019753,0.0001595948,0.0001857148,0.000003504824,0.00001039711,0.00006887094,0.000004513783,0.00291369,0.9941612,0.00003212809,0.002435667,0.000004499386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954302,0.008891953,0.03119693,0.0004213075,0.0001158147,0.0001610685,0.000148394,0.0003836502,0.004378875],"genre_scores_gemma":[0.9816474,0.00224437,0.01275871,0.0001553955,0.00002453919,0.00008086616,0.0001092901,0.00003013925,0.002949168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006657249,"threshold_uncertainty_score":0.002227068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487718185827762,"score_gpt":0.283459879585682,"score_spread":0.2685826977274044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}