{"id":"W4401084082","doi":"10.1021/acsomega.3c09817","title":"Actively Targeting Redox-Responsive Multifunctional Micelles for Synergistic Chemotherapy of Cancer","year":2024,"lang":"en","type":"article","venue":"ACS Omega","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Taiwan Instrument Research Institute, National Applied Research Laboratories; Debre Markos University; Addis Ababa University; National Taiwan University; Bahir Dar University; National Science and Technology Council; Tri-Service General Hospital; University of Waterloo; National Taiwan University of Science and Technology; National Applied Research Laboratories","keywords":"Micelle; PLGA; Ethylene glycol; Zeta potential; Chemistry; Redox; Nanocarriers; PEG ratio; Doxorubicin; Biophysics; Drug delivery; Chemosensitizer; Combinatorial chemistry; Aqueous solution; Nanoparticle; Materials science; Nanotechnology; Organic chemistry; Biochemistry; Cytotoxicity; Chemotherapy; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003681417,0.0001347957,0.000185721,0.0000985961,0.00008661067,0.00005576214,0.0001623726,0.00005685877,0.000159368],"category_scores_gemma":[0.0002625887,0.0001193705,0.00007864068,0.0002074413,0.0001129984,0.000191624,0.00003533244,0.00006583334,0.00007269746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035653,"about_ca_system_score_gemma":0.0002214869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001636794,"about_ca_topic_score_gemma":0.00001618169,"domain_scores_codex":[0.9988554,0.00004783461,0.0002693843,0.0003368778,0.0002276489,0.0002628408],"domain_scores_gemma":[0.9986439,0.0008738867,0.00008923421,0.0001492432,0.000190055,0.00005371308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004666942,0.00005277167,0.00007137738,0.0001056515,0.00003717949,0.000005476375,0.0003191165,0.0007448439,0.9911758,0.0005469302,0.004223194,0.002250931],"study_design_scores_gemma":[0.0004730546,0.000071373,0.0002471505,0.00009585785,0.00003788643,9.698547e-7,0.0001572824,0.002372613,0.9853507,0.0003680055,0.01068192,0.0001431599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994499,0.001853415,0.001278531,0.0006955412,0.001005426,0.0002808986,0.000237479,0.0001008923,0.0000487598],"genre_scores_gemma":[0.9957262,0.00004399525,0.002601691,0.0001624559,0.0002635788,0.0001331976,0.000009658549,0.00003259258,0.001026576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006458729,"threshold_uncertainty_score":0.4867786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01487718185827762,"score_gpt":0.283459879585682,"score_spread":0.2685826977274044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}