{"id":"W4401089771","doi":"10.1021/jacsau.4c00442","title":"Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300","year":2024,"lang":"en","type":"article","venue":"JACS Au","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Innovative Medicines Initiative; European Commission; McGill University; Diamond Light Source; Horizon 2020 Framework Programme; Kungliga Tekniska Högskolan; Dana-Farber Cancer Institute; European Federation of Pharmaceutical Industries and Associations; Center for Cancer Research","keywords":"Biology; CREB-binding protein; Proteasome; Cell biology; Biochemistry; Gene; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001668474,0.0003883616,0.0002135684,0.0001748537,0.0001217917,0.0002418433,0.0002289786,0.0002271267,0.0009531458],"category_scores_gemma":[0.0001468761,0.00008739951,0.0001695185,0.00008648496,0.0002104165,0.0001576574,0.0001352885,0.0004354438,0.0002837989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004340264,"about_ca_system_score_gemma":0.0002783705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008168505,"about_ca_topic_score_gemma":0.001249434,"domain_scores_codex":[0.9998875,0.00001452675,0.000006502057,0.00002672357,0.00003663033,0.00002810846],"domain_scores_gemma":[0.9999233,0.00001568339,0.00002167817,0.0000100393,0.00001178309,0.00001747084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005097687,0.00001243115,0.00005160222,0.00002216116,0.000003041152,0.00002686794,0.000003973706,0.00004958104,0.9978589,0.0001041399,0.00003171798,0.001784412],"study_design_scores_gemma":[0.000004957801,0.0001253692,0.0004611438,0.000001224598,0.00000363107,0.0001195224,0.000002366206,0.0003168055,0.9980705,0.000009935095,0.0008830215,0.000001472293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810797,0.005776144,0.009638606,0.0001455433,0.00003246594,0.00007292892,0.0002683152,0.0001389733,0.002847261],"genre_scores_gemma":[0.9920201,0.001300622,0.003464037,0.0000540093,0.0000109073,0.00002905309,0.0002529397,0.00001462483,0.002853846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009531458,"threshold_uncertainty_score":0.00318855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008328337708035793,"score_gpt":0.2385447975013029,"score_spread":0.2302164597932671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}