{"id":"W4401102136","doi":"10.1002/alz.14065","title":"Osteopontin: A novel marker of pre‐symptomatic sporadic Alzheimer's disease","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Biomedical Imaging and Bioengineering; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; National Institutes of Health; Olav Thon Stiftelsen; UK Dementia Research Institute; Vetenskapsrådet; Hjärnfonden; University College London; Canada Foundation for Innovation; National Institute for Health and Care Research; EU Joint Programme – Neurodegenerative Disease Research; Fondation Brain Canada; Stiftelsen för Gamla Tjänarinnor; Familjen Erling-Perssons Stiftelse; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association; McGill University; European Commission; U.S. Department of Defense","keywords":"Osteopontin; Cerebrospinal fluid; Biomarker; Alzheimer's Disease Neuroimaging Initiative; Amyloid beta; Neuroimaging; Medicine; Disease; Cohort; Alzheimer's disease; Positron emission tomography; Pathology; Oncology; Cognitive decline; Internal medicine; Psychology; Neuroscience; Dementia; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004102616,0.000394449,0.0002722153,0.0006994714,0.0001980401,0.0004541089,0.0002820626,0.000415807,0.0008488707],"category_scores_gemma":[0.0008224326,0.0001331974,0.0001399206,0.000543177,0.0002534355,0.000242234,0.0002857606,0.000317257,0.0001477714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248803,"about_ca_system_score_gemma":0.0002205519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217587,"about_ca_topic_score_gemma":0.001500085,"domain_scores_codex":[0.9998277,0.00002876204,0.00001586302,0.00005577566,0.00005705882,0.00001471124],"domain_scores_gemma":[0.9994951,0.00005692496,0.0003005268,0.00001984293,0.00006349275,0.00006411193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007061178,0.000077387,0.9667686,0.0001509055,0.0001186465,0.0005797978,0.0001793003,0.00008438023,0.01659844,0.00006021378,0.000301143,0.0143751],"study_design_scores_gemma":[0.00002302234,0.0004608809,0.9923877,0.00002955924,0.00006031161,0.00318597,0.0001314383,0.0003004136,0.002438043,0.0001779999,0.0007972966,0.000007410707],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960606,0.00283878,0.000283676,0.00004259697,0.00001294805,0.00001337012,0.0002817831,0.00001200632,0.0004543417],"genre_scores_gemma":[0.9983229,0.0005632286,0.0005665012,0.00002692367,0.00002314789,0.00001564067,0.0001969718,0.000001939819,0.0002826239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217587,"threshold_uncertainty_score":0.002839744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414871049512131,"score_gpt":0.2827081710445094,"score_spread":0.2585594605493881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}