{"id":"W4401105017","doi":"10.1016/j.isci.2024.110621","title":"BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute on Drug Abuse; National Health and Medical Research Council; Queensland Brain Institute; Medical Research Council; National Institutes of Health; Australian Research Council; University of Queensland","keywords":"Dendritic spine; Actin; Cell biology; Actin remodeling; Actin remodeling of neurons; Dendritic filopodia; Neuroscience; Chemistry; Biology; Actin cytoskeleton; Cytoskeleton; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005854937,0.0001712605,0.0001428238,0.0001072714,0.0001665416,0.0001875044,0.0001596631,0.0001838785,0.0008270807],"category_scores_gemma":[0.00009601383,0.0001377266,0.0001273207,0.00006241047,0.0001958472,0.0001511308,0.000234472,0.0004374328,0.0003143058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000498481,"about_ca_system_score_gemma":0.0002415184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001285434,"about_ca_topic_score_gemma":0.003727712,"domain_scores_codex":[0.9999235,0.000005560204,0.000004474687,0.0000170157,0.00002930132,0.00002007583],"domain_scores_gemma":[0.9999282,0.000008178218,0.00002024016,0.000007134869,0.000008705675,0.00002751245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004019335,0.00000651917,0.00009137992,0.00001204159,0.000001736819,0.00001794091,0.000005423164,0.00002995994,0.9991793,0.00008896695,0.00001837548,0.0005081858],"study_design_scores_gemma":[0.00001567495,0.00005365189,0.01243589,0.000006049535,0.000007826463,0.0002202338,0.0000254213,0.001862551,0.9834207,0.00009921237,0.00184915,0.000003498619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959052,0.0007980308,0.001976161,0.00008188099,0.00001380487,0.00001201753,0.0001039216,0.00003139447,0.001077589],"genre_scores_gemma":[0.9951342,0.0003441737,0.001749388,0.00004742918,0.000003790365,0.00001958459,0.0001985745,0.0000181723,0.002484666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001285434,"threshold_uncertainty_score":0.003616691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.073378746219407,"score_gpt":0.3342582749279143,"score_spread":0.2608795287085073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}