{"id":"W4401107765","doi":"10.1038/s41467-024-50774-3","title":"Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; University of Texas Medical Branch","keywords":"Immunogenicity; Virology; Messenger RNA; Biology; Titer; Neutralizing antibody; Antibody; Virus; Germinal center; Molecular biology; Immunology; Gene; B cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003399045,0.0003120899,0.0002270226,0.000246227,0.0001004651,0.0003799202,0.000195137,0.0002795639,0.0006634994],"category_scores_gemma":[0.0002893379,0.0001233261,0.000265518,0.0001067329,0.0001879631,0.0002358413,0.0001784063,0.0003335242,0.0002014983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001989711,"about_ca_system_score_gemma":0.0002300489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002432136,"about_ca_topic_score_gemma":0.0004681495,"domain_scores_codex":[0.9998154,0.0000481315,0.00001436047,0.00003262173,0.00004609779,0.00004348322],"domain_scores_gemma":[0.9998959,0.00002333872,0.00002501845,0.00001417478,0.00001767818,0.00002382674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003104411,0.00009886616,0.0003470782,0.00007575411,0.00001061497,0.00003540069,0.0000206464,0.0007223718,0.991835,0.0002774966,0.00003478584,0.006231524],"study_design_scores_gemma":[0.00005832771,0.003778664,0.001418745,0.00001170912,0.00004768211,0.0001567934,0.00002334663,0.001922955,0.989208,0.00007987102,0.003285474,0.000008460453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913765,0.00145351,0.004787198,0.0000681222,0.00003955784,0.00009758063,0.00009741744,0.00004577103,0.002034362],"genre_scores_gemma":[0.9851755,0.001967324,0.01038684,0.0000510068,0.00001743699,0.0000938522,0.0003201801,0.00002976105,0.001958072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006634994,"threshold_uncertainty_score":0.002219617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04937136599477487,"score_gpt":0.4049251852551584,"score_spread":0.3555538192603835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}