{"id":"W4401113447","doi":"10.1186/s12974-024-03184-7","title":"Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; McGill University","funders":"Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; JW and HM Goodman Family Foundation; McGill University","keywords":"Inflammation; Neuroinflammation; Pathology; Chemistry; Senile plaques; Alzheimer's disease; Neuroscience; Cell biology; Biology; Immunology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003880116,0.0001614982,0.0005018626,0.0005338375,0.00002492436,0.00001779803,0.00004710172,0.00009826044,0.00001471292],"category_scores_gemma":[0.0002370989,0.0001168374,0.00009273808,0.0001537929,0.0001424603,0.0003622861,0.00003399953,0.0002896005,8.772527e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003388253,"about_ca_system_score_gemma":0.0001038445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009488083,"about_ca_topic_score_gemma":0.000004109636,"domain_scores_codex":[0.9984068,0.0003874102,0.0005014467,0.0001995372,0.0003290674,0.0001756932],"domain_scores_gemma":[0.9988323,0.0004959188,0.0002524822,0.00012574,0.0001105232,0.0001829983],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0125973,0.001094217,0.02968724,0.001372408,0.003966899,0.007870014,0.003722851,0.0002964203,0.8272161,0.0002774225,0.0002147965,0.1116843],"study_design_scores_gemma":[0.01601138,0.02891563,0.3163455,0.001550786,0.002816208,0.003381091,0.0002417094,0.04641295,0.5826623,0.001284913,0.000014938,0.0003626264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995877,0.003146658,0.00003705956,0.0003316393,0.0002380785,0.0003215033,0.00001241115,0.000008312002,0.00002732828],"genre_scores_gemma":[0.9992644,0.0004835335,0.00006954818,0.00001264697,0.0001304095,0.000005389047,0.00001228603,0.00002018124,0.000001647579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2866583,"threshold_uncertainty_score":0.4764492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604854419850472,"score_gpt":0.2981141187870561,"score_spread":0.2820655745885514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}