{"id":"W4401113447","doi":"10.1186/s12974-024-03184-7","title":"Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System; McGill University","funders":"Consortium canadien en neurodégénérescence associée au vieillissement; Canadian Institutes of Health Research; JW and HM Goodman Family Foundation; McGill University","keywords":"Inflammation; Neuroinflammation; Pathology; Chemistry; Senile plaques; Alzheimer's disease; Neuroscience; Cell biology; Biology; Immunology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003162499,0.0009999346,0.0005575584,0.001524982,0.0003253009,0.0004859767,0.0002791191,0.0005678334,0.001084013],"category_scores_gemma":[0.0001859825,0.0003393418,0.0004379051,0.0004627822,0.0006616804,0.000574592,0.0003214994,0.001457173,0.0002925835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005332042,"about_ca_system_score_gemma":0.0004293638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174004,"about_ca_topic_score_gemma":0.002273886,"domain_scores_codex":[0.9997528,0.00002546071,0.00002037799,0.00005718866,0.00006687569,0.00007734211],"domain_scores_gemma":[0.9995428,0.00003254387,0.0001649813,0.0000397514,0.00008217686,0.0001376145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002845489,0.0003487359,0.001023886,0.00006486914,0.00002875486,0.000150084,0.00006802982,0.00003604143,0.9932674,0.00006055338,0.000032311,0.002073884],"study_design_scores_gemma":[0.00006285058,0.004243034,0.01446204,0.00001516805,0.0001254185,0.0003674115,0.0001746089,0.0004043173,0.9791594,0.0001424581,0.0008228069,0.00002058981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939765,0.002638696,0.001922777,0.0001116571,0.00005754559,0.00006272327,0.0004670776,0.0001141868,0.0006489152],"genre_scores_gemma":[0.9882497,0.003258248,0.003795663,0.0001199206,0.00003122056,0.0002094983,0.0006126722,0.00003658257,0.003686608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001524982,"threshold_uncertainty_score":0.003868699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01604854419850472,"score_gpt":0.2981141187870561,"score_spread":0.2820655745885514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}