{"id":"W4401120517","doi":"10.1021/acs.orglett.4c02334","title":"Gold(I)-Catalyzed Functionalization of Pyrrole Derivatives: Stereoselective Synthesis of 7,8-Disubstituted 7,8-Dihydroindolizin-6(5<i>H</i>)-ones","year":2024,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Côte d’Azur; Centre National de la Recherche Scientifique; University of Ottawa","keywords":"Chemistry; Cycloisomerization; Nucleophile; Surface modification; Pyrrole; Catalysis; Combinatorial chemistry; Stereoselectivity; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675019,0.0004685768,0.0001872478,0.000170368,0.0001036487,0.0001692248,0.0003031884,0.0002715129,0.001061528],"category_scores_gemma":[0.0001253467,0.0001328323,0.0002081554,0.00009913183,0.0001634918,0.0001852309,0.0002013235,0.0003605302,0.0005072859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002608282,"about_ca_system_score_gemma":0.0001847485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004174186,"about_ca_topic_score_gemma":0.0008788924,"domain_scores_codex":[0.9998794,0.00001928151,0.000009160154,0.00002715682,0.00002723962,0.00003768256],"domain_scores_gemma":[0.999943,0.000006959856,0.00001766061,0.000009058778,0.000009374008,0.00001391726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004065681,0.00001536371,0.00003686611,0.00006067243,0.000004221638,0.0001281105,0.00003070993,0.0002008629,0.9961925,0.0003830264,0.0000605787,0.002846449],"study_design_scores_gemma":[0.000007626169,0.0001276409,0.0002493225,0.000002261009,0.000004300706,0.0001177851,0.000006153261,0.0003271278,0.9971005,0.00003432551,0.00201771,0.000005269773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619989,0.002896475,0.02015391,0.0001844321,0.0001095245,0.0002304203,0.0005254904,0.0002801992,0.01362064],"genre_scores_gemma":[0.9856473,0.001007134,0.01006109,0.00003744314,0.00001079272,0.00003678878,0.000189012,0.00002648071,0.002983915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061528,"threshold_uncertainty_score":0.003551185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008992567234789469,"score_gpt":0.2147307261738273,"score_spread":0.2057381589390378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}