{"id":"W4401120517","doi":"10.1021/acs.orglett.4c02334","title":"Gold(I)-Catalyzed Functionalization of Pyrrole Derivatives: Stereoselective Synthesis of 7,8-Disubstituted 7,8-Dihydroindolizin-6(5<i>H</i>)-ones","year":2024,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Université Côte d’Azur; Centre National de la Recherche Scientifique; University of Ottawa","keywords":"Chemistry; Cycloisomerization; Nucleophile; Surface modification; Pyrrole; Catalysis; Combinatorial chemistry; Stereoselectivity; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001113263,0.0002509307,0.000363183,0.0002175031,0.00004800708,0.00003134534,0.0002158315,0.0001238278,0.001410602],"category_scores_gemma":[0.0001712554,0.0002475587,0.0001580771,0.0006709351,0.0001263607,0.0002758492,0.00005840843,0.0001804133,0.00006898303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441474,"about_ca_system_score_gemma":0.0001459324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006255935,"about_ca_topic_score_gemma":0.00001308496,"domain_scores_codex":[0.9983945,0.0000390748,0.0004957003,0.0004303944,0.0004064844,0.0002338685],"domain_scores_gemma":[0.9989367,0.0002755338,0.0002339012,0.0003579686,0.0001342819,0.00006168663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006247429,0.00006552141,0.0001689192,0.0007681474,0.0002647973,0.000009590523,0.0009229256,0.00003597508,0.9947289,0.0005619273,0.0003148366,0.002095984],"study_design_scores_gemma":[0.0003091729,0.00001253492,0.0001992475,0.0003205987,0.0001630493,0.00003355325,0.0007019126,0.0001936527,0.9970382,0.0001127227,0.0006858001,0.0002295426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884789,0.0003863846,0.008455068,0.0003792429,0.0002870548,0.0001442303,0.00007435949,0.0002540142,0.001540733],"genre_scores_gemma":[0.9990052,0.00003790695,0.0004299452,0.00006457649,0.0001366625,0.00003524643,0.00009796506,0.00007556142,0.0001169166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052631,"threshold_uncertainty_score":0.9999977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008992567234789469,"score_gpt":0.2147307261738273,"score_spread":0.2057381589390378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}