{"id":"W4401123275","doi":"10.1158/1078-0432.ccr-24-1317","title":"Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia; Dalhousie University; Provincial Health Services Authority; BC Cancer Agency","funders":"Canadian Institutes of Health Research; BC Cancer Foundation; eFFECTOR Therapeutics; Alex's Lemonade Stand Foundation for Childhood Cancer; Conquer Cancer Foundation","keywords":"Osteosarcoma; Metastasis; Medicine; Cancer research; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314764,0.0004723278,0.0004933169,0.0002786148,0.0001698771,0.0002099854,0.0002805834,0.0002604602,0.001900007],"category_scores_gemma":[0.0001395154,0.0001400759,0.0003561139,0.000158815,0.0002337713,0.0002043631,0.0001517437,0.0006986717,0.000475833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000228569,"about_ca_system_score_gemma":0.0003546113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002782611,"about_ca_topic_score_gemma":0.0008985072,"domain_scores_codex":[0.9998889,0.00001726739,0.0000170222,0.0000206432,0.00002741749,0.00002876473],"domain_scores_gemma":[0.9999382,0.000009054564,0.00002255286,0.0000075937,0.000009202443,0.00001336702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006148973,0.0003969536,0.0001942223,0.0003330297,0.00003107734,0.00004886989,0.00001330297,0.0001934322,0.9898161,0.0001474728,0.0002661744,0.007944521],"study_design_scores_gemma":[0.0004087217,0.00586156,0.004280535,0.00004961041,0.00009219105,0.0003902917,0.00004906345,0.001492568,0.9765663,0.0001192796,0.01067733,0.00001247504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766548,0.01383389,0.004309862,0.0005647909,0.0002196773,0.0002229912,0.000846096,0.0003644243,0.002983501],"genre_scores_gemma":[0.9878635,0.005571943,0.003327302,0.0001226998,0.00003732246,0.0001511352,0.0005958874,0.00002421427,0.002305973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900007,"threshold_uncertainty_score":0.00635618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1531229650514641,"score_gpt":0.5063316279496912,"score_spread":0.3532086628982272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}