{"id":"W4401123996","doi":"10.7573/dic.2024-5-6","title":"New and emerging oral therapies for psoriasis","year":2024,"lang":"en","type":"review","venue":"Drugs in Context","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Amgen","keywords":"Medicine; Apremilast; Psoriasis; Adverse effect; Acitretin; Methotrexate; Pharmacology; Clinical trial; Intensive care medicine; Dermatology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002513991,0.000440307,0.001345815,0.000274853,0.00008184354,0.00003719704,0.0001931773,0.0005087726,0.0001895797],"category_scores_gemma":[0.00003136662,0.0003186571,0.000405349,0.0001791992,0.00005571561,0.00004807693,0.00007506951,0.0002415881,0.0003574781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005966495,"about_ca_system_score_gemma":0.0001598846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001299361,"about_ca_topic_score_gemma":0.0001516774,"domain_scores_codex":[0.9985485,0.0001683813,0.0004335447,0.0004921691,0.00002211896,0.0003352521],"domain_scores_gemma":[0.9991968,0.0004039891,0.000121657,0.0002364006,0.00001789565,0.00002324982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002647829,0.00001716695,0.000005056123,0.001829803,0.0009723072,0.000003613869,0.001427133,4.640726e-9,0.000002682656,0.001194101,0.008098942,0.9864227],"study_design_scores_gemma":[0.0009346398,0.00005454212,0.00000251552,0.003034069,0.001750577,0.00002135378,0.0004049411,1.403108e-7,0.00001189255,0.0003572073,0.9931227,0.0003054541],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000740639,0.9959613,0.00001933129,0.00008625498,0.002525377,0.0007656373,0.0001770168,0.00006469597,0.0003263395],"genre_scores_gemma":[0.000186949,0.9840304,0.0001399924,0.00003498595,0.000157083,0.0002866354,0.0002760417,0.00005967271,0.01482822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9861172,"threshold_uncertainty_score":0.9999266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04510012189573023,"score_gpt":0.3263494329327066,"score_spread":0.2812493110369764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}