{"id":"W4401125374","doi":"10.1002/ana.27040","title":"Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome","year":2024,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Intramural Research Program; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Government of Canada","keywords":"Restless legs syndrome; Genome-wide association study; Genetic architecture; Genetics; Genetic association; Locus (genetics); Population; Biology; Medicine; Gene; Psychiatry; Single-nucleotide polymorphism; Quantitative trait locus; Genotype; Neurology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007302556,0.0006419662,0.0005649318,0.001257281,0.000368648,0.0007416572,0.0004748043,0.0007301748,0.002692014],"category_scores_gemma":[0.003134197,0.0002580386,0.001571514,0.002311819,0.0003295992,0.0002653605,0.0004669887,0.0005433679,0.0002176561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001875816,"about_ca_system_score_gemma":0.0002741095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003927413,"about_ca_topic_score_gemma":0.003016022,"domain_scores_codex":[0.9991344,0.0002519851,0.00007266693,0.0003690828,0.0001073981,0.00006448675],"domain_scores_gemma":[0.9987226,0.0006006976,0.0004170593,0.00008046202,0.00008347233,0.00009564603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001069658,0.00005468269,0.965876,0.0002594979,0.004844923,0.001629184,0.0001591151,0.0008009557,0.007304482,0.0004312981,0.001244175,0.01632605],"study_design_scores_gemma":[0.00007272394,0.0001209937,0.9929082,0.00006080974,0.002031588,0.001011902,0.00008530913,0.001310409,0.0005668753,0.0006680496,0.001150467,0.00001251173],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9814513,0.01044925,0.003117037,0.0009724293,0.0001126678,0.00002521847,0.002295701,0.000111683,0.001464748],"genre_scores_gemma":[0.9966609,0.00116954,0.000832665,0.0001609269,0.00006868973,0.0000123951,0.0007781714,0.00001568305,0.0003011234],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003927413,"threshold_uncertainty_score":0.009005666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2153573329987432,"score_gpt":0.4630586121192369,"score_spread":0.2477012791204938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}