{"id":"W4401125374","doi":"10.1002/ana.27040","title":"Genomic Analysis Identifies Risk Factors in Restless Legs Syndrome","year":2024,"lang":"en","type":"review","venue":"Annals of Neurology","topic":"Restless Legs Syndrome Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Intramural Research Program; Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Government of Canada","keywords":"Restless legs syndrome; Genome-wide association study; Genetic architecture; Genetics; Genetic association; Locus (genetics); Population; Biology; Medicine; Gene; Psychiatry; Single-nucleotide polymorphism; Quantitative trait locus; Genotype; Neurology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009723994,0.000600846,0.005152128,0.005141437,0.00003674845,0.00004195888,0.0006604606,0.0008090794,0.0002319205],"category_scores_gemma":[0.0004662478,0.0004574428,0.001941276,0.00318074,0.0003401372,0.00007072728,0.0004346727,0.002210333,0.000424351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003839543,"about_ca_system_score_gemma":0.0004453967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009635605,"about_ca_topic_score_gemma":0.0001677908,"domain_scores_codex":[0.9949868,0.001041689,0.001508534,0.001101191,0.0005769213,0.0007848218],"domain_scores_gemma":[0.9970268,0.0007694053,0.0005498176,0.001284161,0.0001341185,0.0002357095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007530909,0.002451329,0.1434205,0.3393643,0.07408842,0.1031467,0.0009927441,0.0003179303,0.00007990358,0.0006838889,0.01883523,0.315866],"study_design_scores_gemma":[0.0003848099,0.00161199,0.1082301,0.005364369,0.02065202,0.002435448,0.00001979876,0.00006306321,0.000009433806,0.0003684815,0.8600893,0.0007711456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.207364,0.7909196,0.00000104246,0.000362555,0.0002267093,0.000669004,0.0001758463,0.00004229185,0.0002389969],"genre_scores_gemma":[0.02969421,0.9688463,0.000004006529,0.00005472942,0.00005531824,0.00007221762,0.0001996702,0.0001230437,0.000950553],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8412541,"threshold_uncertainty_score":0.9997877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2153573329987432,"score_gpt":0.4630586121192369,"score_spread":0.2477012791204938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}