{"id":"W4401134107","doi":"10.1002/alz.14139","title":"A genetic and proteomic comparison of key AD biomarkers across tissues","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Genentech; National Institutes of Health; H. Lundbeck A/S; Selfridges Group Foundation; Servier; Biogen; Pfizer; Alzheimer Nederland; Eisai; Alzheimer's Association; Fujirebio US; Janssen Alzheimer Immunotherapy Research And Development; AbbVie; European Commission; Fondation Brain Canada; Novartis Pharmaceuticals Corporation; Chan Zuckerberg Initiative; GlaxoSmithKline; Eli Lilly and Company; U.S. Department of Defense; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Bristol-Myers Squibb; ZonMw; Michael J. Fox Foundation for Parkinson's Research","keywords":"Apolipoprotein E; Cerebrospinal fluid; Neurodegeneration; Genome-wide association study; TREM2; Biology; Expression quantitative trait loci; Quantitative trait locus; Biomarker; Neurogranin; Blood proteins; Apolipoprotein B; Proteome; Amyloid beta; Receptor; Genetics; Disease; Medicine; Gene; Genotype; Signal transduction; Pathology; Endocrinology; Cholesterol; Neuroscience; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006972489,0.0003388799,0.0003511754,0.001617967,0.0002928299,0.000641252,0.0001958942,0.0002985693,0.001355177],"category_scores_gemma":[0.00100844,0.0001488975,0.0003129015,0.001133143,0.00023266,0.0002105471,0.0004150118,0.0001963404,0.0002500482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002396622,"about_ca_system_score_gemma":0.0001661902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006174928,"about_ca_topic_score_gemma":0.0005400255,"domain_scores_codex":[0.9996163,0.00005909677,0.00003219649,0.0001827468,0.00007666719,0.00003309806],"domain_scores_gemma":[0.9994685,0.0001198699,0.0001938322,0.00005285576,0.0001089088,0.0000559968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003968977,0.0001490648,0.5748545,0.0003397332,0.001109467,0.0007017574,0.0002757984,0.0004581994,0.3890747,0.0003662854,0.0005195157,0.02818193],"study_design_scores_gemma":[0.0000287731,0.0004763105,0.9800957,0.0000209648,0.000276792,0.001753261,0.0001474933,0.0007244564,0.01511204,0.0003943005,0.000955843,0.00001409061],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966809,0.0007727753,0.0009188663,0.00002867365,0.000008946504,0.00001032565,0.001124336,0.00001565351,0.0004395004],"genre_scores_gemma":[0.9960431,0.0002676916,0.001909887,0.00003779356,0.00001171889,0.00002937459,0.001326471,0.00001076463,0.0003631653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617967,"threshold_uncertainty_score":0.00453347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03870512346603983,"score_gpt":0.365255825653719,"score_spread":0.3265507021876792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}