{"id":"W4401146963","doi":"10.4103/nrr.nrr-d-24-00262","title":"Lactate is a potentially harmful substitute for brain glucose fuel: consequences for metabolic restoration of neurotransmission","year":2024,"lang":"en","type":"article","venue":"Neural Regeneration Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glycolysis; Anaerobic glycolysis; Biochemistry; Glycogen; Glucose transporter; Citric acid cycle; Oxidative phosphorylation; Biology; Chemistry; Hexokinase; Metabolism; Endocrinology; Insulin","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007298902,0.0001086045,0.0001311205,0.0001547416,0.0001553172,0.00008716137,0.0001268754,0.0001469951,0.00004070068],"category_scores_gemma":[0.0004918892,0.0000940796,0.000130375,0.0001994102,0.0001388957,0.00001714802,0.00002344143,0.0001120898,0.000005480728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008169237,"about_ca_system_score_gemma":0.000265131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002201739,"about_ca_topic_score_gemma":0.00008075356,"domain_scores_codex":[0.9985881,0.0002605668,0.0002655143,0.0004169444,0.0002339698,0.0002349165],"domain_scores_gemma":[0.9990504,0.0001091193,0.00004253162,0.0002026747,0.0005184567,0.00007676818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005473182,0.00001634221,0.000008465622,0.0001156924,0.00001948844,0.000002520574,0.00006981372,0.0001824149,0.9625397,0.003768415,0.02457171,0.008158104],"study_design_scores_gemma":[0.0003576008,0.0005029528,0.00001936735,0.00001024035,0.00001145244,0.00000945044,0.00001023347,0.004798381,0.7196101,0.0005114197,0.2740907,0.00006813994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7924947,0.007423847,0.1711136,0.02403264,0.001985384,0.002369212,0.0003347458,0.00004847646,0.0001974411],"genre_scores_gemma":[0.9839144,0.001079443,0.004199449,0.0006962058,0.001105897,0.0004509718,0.0008450907,0.00004035728,0.007668238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.249519,"threshold_uncertainty_score":0.3836455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09292355968498667,"score_gpt":0.3938417063479653,"score_spread":0.3009181466629786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}