{"id":"W4401151582","doi":"10.1101/2024.07.29.605674","title":"Oxidation of Four Monoterpenoid Indole Alkaloid Classes by Three Cytochrome P450 Monooxygenases from <i>Tabernaemontana litoralis</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University; University of New Brunswick","funders":"","keywords":"Hydroxylation; Monooxygenase; Stereochemistry; Cytochrome P450; Biosynthesis; Indole test; Biology; Chemistry; Biochemistry; Botany; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity"],"category_scores_codex":[0.001238098,0.001342471,0.001718267,0.0004819279,0.0003107159,0.000213364,0.001565685,0.002371986,0.001379227],"category_scores_gemma":[0.000232765,0.00142712,0.0005733661,0.0006484204,0.0004944189,0.0002729982,0.001387384,0.003185579,0.000482273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007263037,"about_ca_system_score_gemma":0.0009372851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001253332,"about_ca_topic_score_gemma":0.00007371286,"domain_scores_codex":[0.9936547,0.0009567543,0.00167504,0.001926407,0.0006291208,0.00115794],"domain_scores_gemma":[0.9952704,0.0008911678,0.00126809,0.001312947,0.0005785939,0.0006787719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003893502,0.0005782551,0.003532575,0.0006371452,0.001645873,0.0001655659,0.00003550011,0.0001052392,0.9684016,0.0003329941,0.02412727,0.00004871134],"study_design_scores_gemma":[0.001256631,0.0001490439,0.0156304,0.000349261,0.001514563,1.326311e-7,0.000009034839,0.001055593,0.9259987,0.0001426141,0.05254845,0.001345556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665054,0.01901022,0.0005397507,0.0008239608,0.004790057,0.001605579,0.006043064,0.0005929518,0.00008898993],"genre_scores_gemma":[0.9916714,0.002946697,0.001191275,0.001183647,0.002032181,0.0005921897,0.00001854308,0.0003277856,0.0000363014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0424028,"threshold_uncertainty_score":0.9999326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05591647944466898,"score_gpt":0.3246249373849374,"score_spread":0.2687084579402684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}