{"id":"W4401155021","doi":"10.1016/j.bpsc.2024.07.019","title":"Structural Brain Differences in the Alzheimer’s Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; Fondo de Fomento al Desarrollo Científico y Tecnológico; Agencia Estatal de Investigación; National Health and Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Fogarty International Center; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Servier; Eisai; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dementia Collaborative Research Centres, Australia; BioClinica; Biogen; Pfizer; Consejo Nacional de Investigaciones Científicas y Técnicas; ZonMw; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; H. Lundbeck A/S; Centres de Recerca de Catalunya; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; Science and Industry Endowment Fund; European Federation of Pharmaceutical Industries and Associations; Ministerio de Economía y Competitividad; Bristol-Myers Squibb; “la Caixa” Foundation; Agencia Nacional de Investigación y Desarrollo; Generalitat de Catalunya; Australian Government; Novartis Pharmaceuticals Corporation; University of Southern California; Edith Cowan University; U.S. Department of Defense; Eli Lilly and Company; Alzheimer's Association; European Commission; Medical Research Council; Meso Scale Diagnostics","keywords":"Neuroimaging; Neuroscience; Disease; GRASP; Pathological; Alzheimer's disease; Psychology; Medicine; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004494485,0.0004409024,0.0003112052,0.000160357,0.001326478,0.0007263729,0.0007132986,0.00004928249,0.000009570634],"category_scores_gemma":[0.006387269,0.0002337732,0.0001518402,0.0009282892,0.001815235,0.0005826256,0.0005086845,0.0008161835,0.00001513108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001197402,"about_ca_system_score_gemma":0.00006673519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008772252,"about_ca_topic_score_gemma":0.0001464813,"domain_scores_codex":[0.9950716,0.001486505,0.0003882844,0.001915038,0.0004962531,0.0006422558],"domain_scores_gemma":[0.9876033,0.01176944,0.0001086585,0.0003266675,0.00004099549,0.000150911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002339551,0.0001863989,0.9152287,0.00002283611,0.00001211924,0.0006930406,0.002290848,0.000002745931,0.07254891,0.003099144,0.000657577,0.00502372],"study_design_scores_gemma":[0.0004258026,0.0001504861,0.9814699,0.00008336891,0.00004101216,0.00006234544,0.0005515571,0.008111107,0.0007396578,0.00652901,0.001491791,0.0003439519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954573,0.005087677,0.0001495418,0.03682769,0.002330447,0.0006708676,0.00009609897,0.0001674939,0.00009722292],"genre_scores_gemma":[0.9330708,0.0003218968,0.00001025752,0.06624751,0.000247243,0.00007169999,0.000004615548,0.00001838059,0.000007591625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07180925,"threshold_uncertainty_score":0.9999737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08603981402790489,"score_gpt":0.3246057806261335,"score_spread":0.2385659665982287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}