{"id":"W4401155021","doi":"10.1016/j.bpsc.2024.07.019","title":"Structural Brain Differences in the Alzheimer’s Disease Continuum: Insights Into the Heterogeneity From a Large Multisite Neuroimaging Consortium","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias; Fondo de Fomento al Desarrollo Científico y Tecnológico; Agencia Estatal de Investigación; National Health and Medical Research Council; National Institute of Biomedical Imaging and Bioengineering; Fogarty International Center; Canadian Institutes of Health Research; Genentech; National Institutes of Health; IXICO; Servier; Eisai; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Dementia Collaborative Research Centres, Australia; BioClinica; Biogen; Pfizer; Consejo Nacional de Investigaciones Científicas y Técnicas; ZonMw; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; H. Lundbeck A/S; Centres de Recerca de Catalunya; Northern California Institute for Research and Education; Ministerio de Ciencia, Innovación y Universidades; Science and Industry Endowment Fund; European Federation of Pharmaceutical Industries and Associations; Ministerio de Economía y Competitividad; Bristol-Myers Squibb; “la Caixa” Foundation; Agencia Nacional de Investigación y Desarrollo; Generalitat de Catalunya; Australian Government; Novartis Pharmaceuticals Corporation; University of Southern California; Edith Cowan University; U.S. Department of Defense; Eli Lilly and Company; Alzheimer's Association; European Commission; Medical Research Council; Meso Scale Diagnostics","keywords":"Neuroimaging; Neuroscience; Disease; GRASP; Pathological; Alzheimer's disease; Psychology; Medicine; Computer science; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04803296,0.0005180716,0.001524643,0.003957564,0.001073567,0.002918772,0.001640296,0.0009137858,0.001469332],"category_scores_gemma":[0.08106721,0.0004412454,0.003607879,0.006231149,0.001642128,0.001672624,0.003274982,0.0009345938,0.000134039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008151543,"about_ca_system_score_gemma":0.001191068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005709068,"about_ca_topic_score_gemma":0.01034913,"domain_scores_codex":[0.9645169,0.02606581,0.002706554,0.003943658,0.002104023,0.0006630862],"domain_scores_gemma":[0.912885,0.05326626,0.01139322,0.01721275,0.003805093,0.001437684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006286841,0.00005762523,0.9333619,0.0008669554,0.03396293,0.0004013634,0.002063885,0.001504755,0.001097299,0.003574678,0.001501807,0.02097803],"study_design_scores_gemma":[0.0001418318,0.0001782184,0.9623592,0.0007179372,0.0164039,0.0007418595,0.001209724,0.002002681,0.0005553006,0.01222399,0.003388523,0.00007675705],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446709,0.02039739,0.02552892,0.003021357,0.000124304,0.0001788408,0.003286194,0.00007679869,0.002715267],"genre_scores_gemma":[0.9930155,0.0008901845,0.004459478,0.0002619213,0.00004445522,0.000134057,0.001098,0.00003133958,0.00006503367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04803296,"threshold_uncertainty_score":0.2540256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08603981402790489,"score_gpt":0.3246057806261335,"score_spread":0.2385659665982287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}