{"id":"W4401160568","doi":"10.1016/s0140-6736(24)01211-x","title":"Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"Novartis Pharma; Sjögren's Foundation","keywords":"Medicine; Placebo; Internal medicine; Double blind; Disease; Monoclonal antibody; Autoimmune disease; Monoclonal; Placebo-controlled study; Gastroenterology; Antibody; Immunology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002954525,0.001682231,0.003235832,0.0006676367,0.0006063611,0.001192635,0.0009453163,0.002688459,0.003322245],"category_scores_gemma":[0.002783719,0.0007669239,0.002474638,0.0005129808,0.001580384,0.001024738,0.000472962,0.002564863,0.000535766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008223241,"about_ca_system_score_gemma":0.0009287383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008287797,"about_ca_topic_score_gemma":0.001229317,"domain_scores_codex":[0.9987686,0.0006395901,0.0001025917,0.0002085141,0.0001279854,0.0001526412],"domain_scores_gemma":[0.9981537,0.000563391,0.0004043455,0.0001596463,0.0001446255,0.000574352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9505117,0.008312895,0.005440207,0.0005697681,0.00169337,0.0001523178,0.0001579275,0.0003135843,0.009893795,0.0000543141,0.0004559776,0.02244405],"study_design_scores_gemma":[0.7764597,0.1971988,0.02359922,0.00003702937,0.001021929,0.0001487973,0.00007527973,0.0002086416,0.0007009007,0.00008568819,0.0004263626,0.00003760006],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958514,0.002499266,0.0001426137,0.0001905168,0.0001007645,0.0005029844,0.0002421596,0.00002319292,0.000447029],"genre_scores_gemma":[0.9962325,0.00105121,0.000348869,0.000532019,0.0002143965,0.0005120326,0.0004860222,0.000008616423,0.0006144494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003322245,"threshold_uncertainty_score":0.01562524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651637123481628,"score_gpt":0.3211007905202314,"score_spread":0.2845844192854151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}