{"id":"W4401160568","doi":"10.1016/s0140-6736(24)01211-x","title":"Safety and efficacy of subcutaneous iscalimab (CFZ533) in two distinct populations of patients with Sjögren's disease (TWINSS): week 24 results of a randomised, double-blind, placebo-controlled, phase 2b dose-ranging study","year":2024,"lang":"en","type":"article","venue":"The Lancet","topic":"Salivary Gland Disorders and Functions","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"Novartis Pharma; Sjögren's Foundation","keywords":"Medicine; Placebo; Internal medicine; Double blind; Disease; Monoclonal antibody; Autoimmune disease; Monoclonal; Placebo-controlled study; Gastroenterology; Antibody; Immunology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004144285,0.0001673074,0.0008311585,0.0001739244,0.00006674253,0.00001415838,0.00009500814,0.00002402204,0.0000294829],"category_scores_gemma":[0.0001787949,0.00009447262,0.0001089728,0.0004030137,0.0001172809,0.00005377581,0.00003592152,0.0001525868,0.00000108353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965169,"about_ca_system_score_gemma":0.00007916304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003676712,"about_ca_topic_score_gemma":0.0002983583,"domain_scores_codex":[0.9985283,0.0001134936,0.0006271614,0.0002435848,0.0002933792,0.0001940691],"domain_scores_gemma":[0.9987003,0.0005384833,0.0001739974,0.0004259283,0.0000768002,0.00008446422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8778299,0.002685336,0.115967,0.0001754542,0.0002801512,0.00004715954,0.001589888,0.0004885445,0.00001428624,0.0001456545,0.0001463721,0.000630206],"study_design_scores_gemma":[0.8837737,0.001368538,0.1099285,0.000351066,0.001186955,0.000006441059,0.0004433574,0.002638341,0.000006486111,0.0001012381,0.00007299498,0.0001223789],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941628,0.000580312,0.0001262033,0.0006996601,0.0001251521,0.002896565,0.0004659121,0.00003164226,0.0009117259],"genre_scores_gemma":[0.9994168,0.00002418292,0.00004828484,0.00002206579,0.00009586471,0.00005660313,0.0002013626,0.00001934277,0.0001155543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006038542,"threshold_uncertainty_score":0.3852482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03651637123481628,"score_gpt":0.3211007905202314,"score_spread":0.2845844192854151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}