{"id":"W4401167844","doi":"10.1016/j.jacbts.2024.05.011","title":"SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics","year":2024,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Bioenergetics; Cardiac dysfunction; Lamin; Internal medicine; Mitochondrion; Cardiology; Mitochondrial DNA; Medicine; Energy metabolism; Cell biology; Biology; Heart failure; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440743,0.0001362035,0.00008783636,0.0001062651,0.0002288696,0.0001567236,0.000177379,0.00009756943,0.00003486651],"category_scores_gemma":[0.00007891932,0.0001215286,0.00007406218,0.0007103356,0.0001079872,0.00002957403,0.00003051064,0.0001011276,0.00004087059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002595016,"about_ca_system_score_gemma":0.0002079836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002036123,"about_ca_topic_score_gemma":0.00001128861,"domain_scores_codex":[0.9985579,0.00003535101,0.0001839534,0.0005619429,0.0003910246,0.0002697975],"domain_scores_gemma":[0.9995633,0.00001889691,0.00002697561,0.0001700456,0.0001019477,0.0001188243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002254179,0.00001291442,0.0002185897,0.00000988372,0.000006409277,5.159897e-7,0.0001299871,0.0001238841,0.9705901,0.0005916905,0.002215138,0.02607836],"study_design_scores_gemma":[0.0002587861,0.0005051585,0.007807609,0.00003774857,0.00004015945,0.00001094668,0.00009132773,0.003236,0.8726958,0.0005467586,0.1143224,0.0004473155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854614,0.0004573098,0.008923555,0.001186982,0.002359023,0.0002575814,0.00004981445,0.00005403995,0.001250264],"genre_scores_gemma":[0.9971356,0.00001133755,0.001712243,0.0001522433,0.0006334374,0.00001523542,0.00007536886,0.00001661418,0.0002479382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1121073,"threshold_uncertainty_score":0.4955794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006747723144879147,"score_gpt":0.2390748087753737,"score_spread":0.2323270856304945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}