{"id":"W4401167844","doi":"10.1016/j.jacbts.2024.05.011","title":"SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics","year":2024,"lang":"en","type":"article","venue":"JACC Basic to Translational Science","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Bioenergetics; Cardiac dysfunction; Lamin; Internal medicine; Mitochondrion; Cardiology; Mitochondrial DNA; Medicine; Energy metabolism; Cell biology; Biology; Heart failure; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634086,0.0005494553,0.0005298432,0.0004098352,0.0002080911,0.0002371448,0.0003347305,0.0004148483,0.001644288],"category_scores_gemma":[0.0000936996,0.0001260204,0.0003446552,0.0001353006,0.0003382458,0.0002720752,0.0002226578,0.0009063766,0.0002654205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418772,"about_ca_system_score_gemma":0.0003173799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003118529,"about_ca_topic_score_gemma":0.0008548936,"domain_scores_codex":[0.9999192,0.00001568693,0.000009426335,0.00001526244,0.00001806314,0.00002235555],"domain_scores_gemma":[0.9999129,0.00000462785,0.00003132294,0.000007172911,0.000009085906,0.00003493653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001208274,0.0003318509,0.0002558541,0.0001596567,0.00002602983,0.00008030792,0.00001923204,0.0001418246,0.9913265,0.0001531462,0.0002033174,0.006094055],"study_design_scores_gemma":[0.0004795342,0.006582274,0.009702195,0.00004456835,0.0001520855,0.0004192185,0.00008474891,0.001967051,0.9715381,0.0003194991,0.008688072,0.0000227286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887879,0.004344182,0.003561347,0.0004640323,0.0002022642,0.00006261157,0.0004176765,0.0004739207,0.001686058],"genre_scores_gemma":[0.9907053,0.002629803,0.002371529,0.0002057194,0.00005506211,0.00006212672,0.0005443308,0.00004609993,0.00338009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644288,"threshold_uncertainty_score":0.005500674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006747723144879147,"score_gpt":0.2390748087753737,"score_spread":0.2323270856304945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}