{"id":"W4401169261","doi":"10.1126/scitranslmed.adn6605","title":"A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates","year":2024,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"","keywords":"Malaria; Vaccination; Immunology; Adjuvant; Immune system; Medicine; Malaria vaccine; Vaccination schedule; Antibody; Virology; Immunization; Interferon; Biology; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007462619,0.0007286227,0.0003681761,0.0005792083,0.0002685248,0.0003610061,0.0004111816,0.0006628607,0.001726742],"category_scores_gemma":[0.0004027763,0.0002543685,0.0003363135,0.0002015617,0.0003356836,0.0003973909,0.0001813992,0.001068487,0.0004504879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003271439,"about_ca_system_score_gemma":0.0003837289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005655042,"about_ca_topic_score_gemma":0.0006749263,"domain_scores_codex":[0.9996051,0.0001569902,0.00002520265,0.00006239163,0.00007059346,0.00007978381],"domain_scores_gemma":[0.9997634,0.00005560579,0.00005023148,0.00003536735,0.00004467237,0.00005070062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00278026,0.001947245,0.0002130536,0.0001755482,0.00002489729,0.0000699024,0.00007898961,0.0005558666,0.9855227,0.0003350005,0.0001655555,0.008130984],"study_design_scores_gemma":[0.0008161741,0.09444474,0.00300516,0.00004630189,0.0001493159,0.0005770907,0.0001129745,0.002445117,0.887187,0.0004040247,0.01077769,0.00003438237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889767,0.002720024,0.003843601,0.0001200952,0.0001049799,0.000509055,0.0003877318,0.00008533514,0.003252552],"genre_scores_gemma":[0.9862339,0.002418447,0.005471093,0.0001391728,0.0001099571,0.0006916611,0.0008379886,0.00003556643,0.004062205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726742,"threshold_uncertainty_score":0.005776525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0903685884792792,"score_gpt":0.4356554750823444,"score_spread":0.3452868866030652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}