{"id":"W4401173915","doi":"10.1016/j.molcel.2024.07.003","title":"The V-ATPase/ATG16L1 axis is controlled by the V1H subunit","year":2024,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Medical Research Council; Francis Crick Institute; Cancer Research UK; Wellcome Trust","keywords":"Biology; Cell biology; Autophagy; Organelle; ATG16L1; Ubiquitin; Protein subunit; ATG8; ATPase; Membrane; Biophysics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000244128,0.0001658097,0.000207752,0.00002911021,0.0001869697,0.0001039936,0.0001985878,0.00007225964,0.0004959825],"category_scores_gemma":[0.00002508289,0.00008141859,0.0003056454,0.0001487539,0.0001095141,0.00002337587,0.00003261343,0.0002456864,0.0005258018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002900575,"about_ca_system_score_gemma":0.0001010695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000286773,"about_ca_topic_score_gemma":0.000001319203,"domain_scores_codex":[0.9988961,0.00009581508,0.0001943519,0.0002287261,0.0003160358,0.0002689423],"domain_scores_gemma":[0.9990899,0.0001713988,0.00003231268,0.0005557004,0.00004389224,0.0001068107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001799488,0.0004905626,0.0001172797,0.0002251165,0.002022477,0.002345764,0.001849557,0.000009466727,0.3086535,0.006604464,0.6381466,0.03773563],"study_design_scores_gemma":[0.003254026,0.0001516736,0.00004472235,0.00003880865,0.0003556685,0.0000174725,0.0001109952,0.001297028,0.1800396,0.001582871,0.812969,0.0001381937],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5849519,0.2595514,0.002379199,0.05107358,0.0008833763,0.002210882,0.00007205957,0.0003756521,0.09850197],"genre_scores_gemma":[0.9609745,0.0006993045,0.00001198155,0.008098297,0.0001093385,0.00008832052,0.00002155668,0.00004439622,0.02995238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3760226,"threshold_uncertainty_score":0.6758294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004695814188045361,"score_gpt":0.2443252113219715,"score_spread":0.2396293971339262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}