{"id":"W4401191002","doi":"10.1101/2024.07.30.605451","title":"Hypersynchronous iPSC-derived <i>SHANK2</i> neuronal networks are rescued by mGluR5 agonism","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Neuroscience; Bursting; Glutamatergic; Biology; Postsynaptic potential; Neurotransmission; Phenotype; Glutamate receptor; Gene; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000375274,0.001212208,0.0009088911,0.0003891915,0.0004522132,0.0009601642,0.001756809,0.0006905438,0.00004746601],"category_scores_gemma":[0.0005574047,0.00127494,0.0003833222,0.001240074,0.0004055055,0.0003253828,0.002014724,0.002997356,0.0002690803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304282,"about_ca_system_score_gemma":0.0004071245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001983851,"about_ca_topic_score_gemma":8.879143e-7,"domain_scores_codex":[0.9934098,0.0002465668,0.0008060114,0.003038553,0.0009388995,0.001560141],"domain_scores_gemma":[0.9967614,0.0002371708,0.0004358935,0.0017876,0.0001313576,0.0006465378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002687409,0.0001073019,0.00004215663,0.0002706609,0.00001877025,0.0005945559,0.000005728624,0.001588735,0.9947817,0.0001832449,0.002375067,0.000005199754],"study_design_scores_gemma":[0.000388485,0.00009779251,0.0009221757,0.0004686921,0.00009587554,4.083451e-7,0.000001568317,0.03253258,0.9555261,0.00000476106,0.008549214,0.001412386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843799,0.001672102,0.0009909562,0.0009674031,0.008306756,0.001022591,0.0005264085,0.00210083,0.00003302221],"genre_scores_gemma":[0.9947865,0.0008750859,0.0001848117,0.002531516,0.0009372099,0.0002490975,4.092395e-7,0.0003884009,0.00004696559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03925565,"threshold_uncertainty_score":0.9993027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636867206187992,"score_gpt":0.2121147419390016,"score_spread":0.1957460698771216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}