{"id":"W4401196631","doi":"10.1101/2024.07.30.605823","title":"Immunodominant extracellular loops of <i>Treponema pallidum</i> FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Syphilis Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; University of Connecticut Health Center; McGovern Medical School; University of Texas Health Science Center at Houston","keywords":"Treponema; Bacterial outer membrane; Microbiology; Antibody; Inhibitory postsynaptic potential; Syphilis; Virology; Opsonin; Extracellular; Biology; Chemistry; Immunology; Cell biology; Biochemistry; Escherichia coli; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005028349,0.0009790234,0.001611497,0.0004579831,0.0001266849,0.0001662681,0.000240447,0.0005648547,0.00004075318],"category_scores_gemma":[0.0001010599,0.0007711785,0.0003190842,0.0003431601,0.0004376188,0.0001147508,0.0006204919,0.0009341266,0.00002168169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000288681,"about_ca_system_score_gemma":0.0007749725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221235,"about_ca_topic_score_gemma":0.00001125564,"domain_scores_codex":[0.9963202,0.0001205807,0.0008508817,0.001360662,0.000707623,0.0006400131],"domain_scores_gemma":[0.9971912,0.0001394709,0.0005492913,0.00137733,0.0004588471,0.0002838546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004281828,0.001012049,0.03542371,0.009032612,0.002226498,0.002376126,0.0001282729,0.000005441673,0.9484391,0.0008041859,0.0001049895,0.00001886347],"study_design_scores_gemma":[0.001915248,0.0005409632,0.09039044,0.007580339,0.001603414,0.0000017105,0.00002834305,0.00004306052,0.8966378,0.00000653706,0.0004527961,0.0007993644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548166,0.04124678,0.00006161641,0.0005753321,0.0005177874,0.002177267,0.0003007868,0.0002803184,0.0000235079],"genre_scores_gemma":[0.9910012,0.004918394,0.002649573,0.00007834214,0.0003742831,0.000684137,0.000001550813,0.0002527916,0.00003973573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05496673,"threshold_uncertainty_score":0.9994739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110895211162631,"score_gpt":0.2183867460405299,"score_spread":0.2072777939289036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}