{"id":"W4401208972","doi":"10.1200/po.24.00094","title":"Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre; University of Ottawa; McGill University","funders":"","keywords":"Germline; Renal cell carcinoma; Medicine; Genetic predisposition; Oncology; Internal medicine; CHEK2; Odds ratio; Genetic testing; BAP1; Cancer; Kidney cancer; Germline mutation; Clear cell renal cell carcinoma; Biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003431368,0.00017253,0.0003549345,0.0002047239,0.00009257344,0.00002939368,0.00008631526,0.0001597392,0.0001084567],"category_scores_gemma":[0.000133253,0.0001375544,0.000129502,0.0002068769,0.00005621754,0.00003697483,0.000114776,0.0001525122,0.00005252973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002989709,"about_ca_system_score_gemma":0.000222588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003644996,"about_ca_topic_score_gemma":0.00005232709,"domain_scores_codex":[0.9984908,0.0000665521,0.0003900526,0.0006357082,0.0001262868,0.0002906783],"domain_scores_gemma":[0.9983079,0.0007400264,0.00004407135,0.000443324,0.0001486785,0.0003160298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0010673,0.0003741411,0.0539442,0.0002607783,0.00006010121,0.0001319082,0.0005711011,0.000059573,0.2069515,0.0002252496,0.01921105,0.7171431],"study_design_scores_gemma":[0.001596222,0.00494813,0.8660266,0.00006159153,0.0002620318,0.0003520012,0.00004588172,0.001179833,0.0125348,0.0008816979,0.1119395,0.0001717816],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583529,0.002517122,0.02936253,0.006267223,0.0001857995,0.001580748,0.00004983147,0.00008202485,0.001601888],"genre_scores_gemma":[0.9054967,0.00004075597,0.09182622,0.000385968,0.0002702252,0.0002848751,0.00004556486,0.00003092892,0.001618731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8120824,"threshold_uncertainty_score":0.5609306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05107389019641016,"score_gpt":0.3599442137011169,"score_spread":0.3088703235047067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}