{"id":"W4401208972","doi":"10.1200/po.24.00094","title":"Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre; University of Ottawa; McGill University","funders":"","keywords":"Germline; Renal cell carcinoma; Medicine; Genetic predisposition; Oncology; Internal medicine; CHEK2; Odds ratio; Genetic testing; BAP1; Cancer; Kidney cancer; Germline mutation; Clear cell renal cell carcinoma; Biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00276865,0.000379619,0.0004028147,0.001134254,0.0009616599,0.0008811426,0.00110404,0.0008204248,0.001529196],"category_scores_gemma":[0.01523841,0.0001226859,0.0003026529,0.001404438,0.001890205,0.0003988621,0.0006007485,0.0007774527,0.00009654606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002370703,"about_ca_system_score_gemma":0.004901848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3175186,"about_ca_topic_score_gemma":0.2753913,"domain_scores_codex":[0.9980951,0.0004681174,0.0001097362,0.000313013,0.000712605,0.0003014951],"domain_scores_gemma":[0.9937884,0.003083634,0.001134331,0.0002462517,0.001116857,0.0006305037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001086735,0.0000229056,0.9762862,0.00006136992,0.00004921848,0.0006943481,0.0002119704,0.0003725641,0.0008807455,0.0004928516,0.0007941083,0.02002521],"study_design_scores_gemma":[0.00001747579,0.0001105751,0.9892963,0.0001984129,0.0001585964,0.002991562,0.0009289904,0.001823753,0.0004406677,0.001262274,0.002752263,0.00001926204],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719386,0.008078557,0.001256413,0.01101334,0.0001197682,0.00004026412,0.0005773893,0.00005933084,0.006916372],"genre_scores_gemma":[0.9964679,0.001580293,0.0009316733,0.0006225792,0.0001076339,0.000005308069,0.000122029,0.00000723319,0.0001553321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3175186,"threshold_uncertainty_score":0.6313409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05107389019641016,"score_gpt":0.3599442137011169,"score_spread":0.3088703235047067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}