{"id":"W4401209608","doi":"10.3390/biom14080922","title":"Complex Interplay between DNA Damage and Autophagy in Disease and Therapy","year":2024,"lang":"en","type":"review","venue":"Biomolecules","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Heart and Stroke Foundation of Canada","keywords":"Autophagy; DNA damage; Context (archaeology); Biology; DNA repair; Cancer; Disease; Cancer research; Programmed cell death; Bioinformatics; Medicine; DNA; Genetics; Apoptosis; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001140468,0.0004540414,0.001242079,0.0003602715,0.0000354814,0.00007201661,0.0001220304,0.0001867807,0.00007442387],"category_scores_gemma":[0.00001798893,0.0003161833,0.0002355456,0.0002525833,0.0002707427,0.00003811178,0.0001179599,0.000255138,0.00004360802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004219105,"about_ca_system_score_gemma":0.0001902044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001780738,"about_ca_topic_score_gemma":0.000001983778,"domain_scores_codex":[0.9985018,0.0001159199,0.0004156366,0.000550063,0.0001627246,0.0002538221],"domain_scores_gemma":[0.9991357,0.00007861226,0.00008709625,0.0003489325,0.00001471766,0.0003349225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005073233,0.00009299377,0.00008749922,0.0113062,0.0005545734,0.001256107,0.0001081713,1.68107e-9,0.00005245292,0.0003773784,0.0006268799,0.985487],"study_design_scores_gemma":[0.0008023205,0.0001481741,0.003761456,0.01145994,0.001435498,0.00004240312,0.00001257384,0.00001060668,0.00002000997,0.0004152828,0.9815133,0.0003784229],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006700735,0.9917107,0.000008060171,0.0001845208,0.00007194983,0.000829082,0.0002659257,0.00008653927,0.0001424466],"genre_scores_gemma":[0.004242084,0.9944112,0.00004632195,0.0002857532,0.0002171825,0.00007558284,0.0004248788,0.00008408373,0.0002128931],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9851086,"threshold_uncertainty_score":0.999929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06731449873720582,"score_gpt":0.4105171082510598,"score_spread":0.343202609513854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}