{"id":"W4401219445","doi":"10.1016/j.omton.2024.200851","title":"Minimally modified off-the-shelf allogeneic CAR T cells","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"BC Cancer Foundation; Canadian Institutes of Health Research; Fonds Léon Fredericq; Terry Fox Research Institute; Michael Smith Health Research BC","keywords":"Chimeric antigen receptor; Cell therapy; Medicine; Cancer research; In vivo; Induced pluripotent stem cell; Immunotherapy; Stem cell; Immunology; Chemistry; Biology; Biotechnology; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073211,0.000323587,0.0002589384,0.0003276449,0.00008456981,0.0004908518,0.000439534,0.0004534578,0.004233159],"category_scores_gemma":[0.0002169669,0.000116393,0.0003342158,0.0002257542,0.0001251037,0.0003165033,0.0003059437,0.0006441416,0.002886221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028672,"about_ca_system_score_gemma":0.0003062101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021187,"about_ca_topic_score_gemma":0.0005340951,"domain_scores_codex":[0.9997926,0.0000256465,0.00001123068,0.00003895675,0.0001066231,0.00002490489],"domain_scores_gemma":[0.9999238,0.00001097564,0.00001804043,0.00001150318,0.00002215002,0.00001355406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005313289,0.0002488106,0.0003833563,0.0007208773,0.00003134978,0.0002731688,0.00004648892,0.0004301641,0.884795,0.001120448,0.004878122,0.1065411],"study_design_scores_gemma":[0.0001346033,0.002723017,0.002126734,0.00009990302,0.0001346767,0.00205251,0.0000582437,0.001273533,0.7992022,0.0005907794,0.1915743,0.00002949739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.702971,0.09933576,0.1114213,0.001928047,0.001891614,0.002044213,0.009316733,0.002769318,0.06832194],"genre_scores_gemma":[0.8410843,0.03676528,0.05264643,0.001933723,0.0002512269,0.001163234,0.01328874,0.0003009354,0.05256621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004233159,"threshold_uncertainty_score":0.01416129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03441878770243568,"score_gpt":0.343309674273072,"score_spread":0.3088908865706363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}