{"id":"W4401222832","doi":"10.1192/bjo.2024.230","title":"CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics","year":2024,"lang":"en","type":"article","venue":"BJPsych Open","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Placebo; Schizophrenia (object-oriented programming); Medicine; Montreal Cognitive Assessment; Clinical endpoint; Randomized controlled trial; Positive and Negative Syndrome Scale; Antipsychotic; Clinical trial; Psychiatry; Cognition; Adverse effect; Internal medicine; Psychosis; Cognitive impairment","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0040224,0.002502115,0.002451148,0.0004960452,0.0006805106,0.001081242,0.0006278791,0.002107352,0.01084964],"category_scores_gemma":[0.003469988,0.0006720488,0.001349536,0.0005745362,0.0009118058,0.001185915,0.0004969356,0.002121538,0.001593069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008942879,"about_ca_system_score_gemma":0.002249298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009741394,"about_ca_topic_score_gemma":0.002973474,"domain_scores_codex":[0.9985608,0.0008252972,0.0001062978,0.0001977075,0.0001065142,0.0002033228],"domain_scores_gemma":[0.9986308,0.0002956326,0.0004195852,0.0001009025,0.0001615314,0.0003913837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9713516,0.003706169,0.00132428,0.00124453,0.0008360068,0.00007406726,0.00006538384,0.0004474818,0.002689113,0.0003058909,0.003402141,0.01455338],"study_design_scores_gemma":[0.9579503,0.03422393,0.004037997,0.00007928359,0.0004103155,0.00004802473,0.00002111445,0.0003173649,0.0002895022,0.0002792476,0.002322718,0.000020204],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8257036,0.01041463,0.003627347,0.00225139,0.0008820557,0.1294754,0.01495476,0.0005008944,0.01218999],"genre_scores_gemma":[0.7769732,0.005696137,0.007294919,0.003510221,0.0006469705,0.1866064,0.007581354,0.0001147093,0.011576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01084964,"threshold_uncertainty_score":0.03629559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09124884826754752,"score_gpt":0.4439954177844161,"score_spread":0.3527465695168686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}