{"id":"W4401224150","doi":"10.26434/chemrxiv-2024-wn5jd","title":"Targeted Genome Mining Facilitates the Discovery of a Promiscuous, Hyperthermostable Amidase from Thermovenabulum gondwanense with Notable Nylon-Degrading Capacity","year":2024,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"biodegradable polymer synthesis and properties","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nylon 6; Amidase; Polyamide; Degradation (telecommunications); Chemistry; Hydrolysis; Polymer; Materials science; Computer science; Polymer chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003840892,0.000585519,0.0005665249,0.0007290425,0.0002904653,0.0009599366,0.0003463074,0.0007810333,0.000738394],"category_scores_gemma":[0.0006214197,0.0001948239,0.0006575202,0.001304889,0.0002053544,0.0004038477,0.0006677646,0.0008984524,0.0006867812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003064505,"about_ca_system_score_gemma":0.0005071573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526043,"about_ca_topic_score_gemma":0.002449577,"domain_scores_codex":[0.9998092,0.00002177286,0.00001999717,0.00005885505,0.00005868959,0.00003158388],"domain_scores_gemma":[0.9998042,0.00006141301,0.00005083361,0.0000272224,0.00003495193,0.00002137779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001058654,0.00004991139,0.00157704,0.0001556074,0.00001963088,0.0002576542,0.00008592359,0.0002360699,0.9864163,0.00009648753,0.0001173711,0.01088218],"study_design_scores_gemma":[0.00005099435,0.0004452812,0.04512918,0.00009991591,0.0001944067,0.002486751,0.0004963699,0.005736071,0.9248047,0.0005807412,0.01992686,0.00004869155],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9540423,0.002659587,0.02966199,0.0007209201,0.00005488738,0.0001960157,0.009777159,0.0003688621,0.002518076],"genre_scores_gemma":[0.8859854,0.004121322,0.07490657,0.0003050159,0.00003443102,0.00021599,0.02936566,0.0002232524,0.00484237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526043,"threshold_uncertainty_score":0.003034353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02697058992855898,"score_gpt":0.2025639243196387,"score_spread":0.1755933343910798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}