{"id":"W4401229376","doi":"10.1038/s41698-024-00643-5","title":"Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials","year":2024,"lang":"en","type":"article","venue":"npj Precision Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Human Genome Research Institute; American Cancer Society; University of Florida Health; St. Baldrick's Foundation; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Medicine; Internal medicine; Cohort; Etoposide; Oncology; Daunorubicin; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003514727,0.0004319225,0.0008111456,0.0004474308,0.000234203,0.0008647956,0.0004169235,0.0003925687,0.0009749286],"category_scores_gemma":[0.002922465,0.0001955874,0.0006758477,0.0008337529,0.0003210825,0.0004760918,0.0006632768,0.0005498477,0.0002590614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003210586,"about_ca_system_score_gemma":0.0004720647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003457977,"about_ca_topic_score_gemma":0.001195556,"domain_scores_codex":[0.9986566,0.0005681835,0.0001381777,0.0003591133,0.0001981604,0.0000796092],"domain_scores_gemma":[0.9985995,0.0005494276,0.0003594184,0.0001966768,0.0001293561,0.000165642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0222784,0.0005493268,0.8543751,0.000445403,0.003966413,0.0001856321,0.0002921043,0.003603231,0.0186558,0.0003212747,0.003013882,0.09231336],"study_design_scores_gemma":[0.005995907,0.009323341,0.9441762,0.0001491646,0.006045297,0.0009780753,0.0002279764,0.005444702,0.008948918,0.001251251,0.01739153,0.00006783958],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934849,0.002644737,0.0007746337,0.0001686854,0.0000237341,0.0001001334,0.00199219,0.00002969729,0.0007812798],"genre_scores_gemma":[0.9893718,0.0007401728,0.001692812,0.0002164005,0.00004207425,0.0001762086,0.007374928,0.00001849088,0.0003669832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003514727,"threshold_uncertainty_score":0.01858783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02851925446708302,"score_gpt":0.3635928269880717,"score_spread":0.3350735725209887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}