{"id":"W4401230917","doi":"10.1136/annrheumdis-2024-eular.369","title":"AB0403 INFLUENCE OF BODY WEIGHT, SEX AND PRIOR BIOLOGIC HISTORY ON TREATMENT OUTCOMES ASSOCIATED WITH TAK-279, A HIGHLY SELECTIVE ORAL TYROSINE KINASE 2 (TYK2) INHIBITOR, IN A PHASE 2B RANDOMIZED TRIAL IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Randomized controlled trial; Medicine; Internal medicine; Tyrosine-kinase inhibitor; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171967,0.0002622466,0.001155847,0.0002785588,0.00003410132,0.00001273959,0.00006385946,0.00005279226,0.00002377789],"category_scores_gemma":[0.001355768,0.0001311755,0.0001858349,0.0003155043,0.0002345942,0.0001384832,0.00002045161,0.000132459,8.183436e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002706541,"about_ca_system_score_gemma":0.0003698248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005031962,"about_ca_topic_score_gemma":0.00009907068,"domain_scores_codex":[0.9982962,0.00033157,0.0006037164,0.0002745804,0.0002988161,0.0001951346],"domain_scores_gemma":[0.9981714,0.00100593,0.0003720312,0.0002048399,0.0001627883,0.00008296196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9153811,0.01951151,0.03045155,0.0004207273,0.002957128,0.00005969332,0.004829163,0.000186763,0.0003439244,0.0002048459,0.0003892916,0.02526436],"study_design_scores_gemma":[0.7362572,0.0135087,0.2349428,0.01013467,0.000787131,0.00000216535,0.0001454238,0.0006552908,0.002969658,0.0002980626,0.00002717166,0.0002717689],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962493,0.0009026156,0.000001940522,0.0002670588,0.0001040558,0.002205379,0.0002142609,0.00002753784,0.00002789499],"genre_scores_gemma":[0.999282,0.0002279351,0.0000177461,0.00008446363,0.00001121898,0.0002543054,0.00005041174,0.00001980335,0.00005213154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2044912,"threshold_uncertainty_score":0.5349181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051590058202626,"score_gpt":0.2923961129232088,"score_spread":0.2718802123411825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}