{"id":"W4401230917","doi":"10.1136/annrheumdis-2024-eular.369","title":"AB0403 INFLUENCE OF BODY WEIGHT, SEX AND PRIOR BIOLOGIC HISTORY ON TREATMENT OUTCOMES ASSOCIATED WITH TAK-279, A HIGHLY SELECTIVE ORAL TYROSINE KINASE 2 (TYK2) INHIBITOR, IN A PHASE 2B RANDOMIZED TRIAL IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Randomized controlled trial; Medicine; Internal medicine; Tyrosine-kinase inhibitor; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001366067,0.0008454834,0.002002167,0.0003284684,0.0003232808,0.0008049802,0.0005299922,0.0009864409,0.006897838],"category_scores_gemma":[0.001271239,0.0003546348,0.001925527,0.0003589776,0.0005616064,0.0007174911,0.0002344248,0.002024879,0.0007683904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003849449,"about_ca_system_score_gemma":0.0007879189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008234191,"about_ca_topic_score_gemma":0.001861777,"domain_scores_codex":[0.9993765,0.0003415421,0.0000496314,0.00007538014,0.00004612696,0.0001108156],"domain_scores_gemma":[0.9992476,0.000275421,0.0001248103,0.00004614728,0.00005946623,0.0002465867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9670923,0.003240325,0.002376253,0.000265792,0.001920947,0.00004221699,0.00001726495,0.0003738975,0.003133295,0.00008136078,0.0007414698,0.02071491],"study_design_scores_gemma":[0.7678606,0.2022507,0.02225858,0.00007447698,0.003119716,0.0001199093,0.0000651236,0.001560345,0.001085232,0.0003487589,0.001221412,0.00003513972],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922106,0.003794682,0.0002525855,0.0004685389,0.0004037452,0.0002718627,0.000666564,0.00006150619,0.001869854],"genre_scores_gemma":[0.9955037,0.001018263,0.0003521492,0.0004813098,0.0003046278,0.0002943774,0.0005420326,0.00001073013,0.001492766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006897838,"threshold_uncertainty_score":0.02307558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051590058202626,"score_gpt":0.2923961129232088,"score_spread":0.2718802123411825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}