{"id":"W4401231822","doi":"10.1136/annrheumdis-2024-eular.25","title":"AB0472 EFFICACY OF GUSELKUMAB IN BIONAIVE PSORIATIC ARTHRITIS PATIENTS WITH SEVERE DISEASE ACTIVITY: POST-HOC ANALYSIS OF A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Psoriatic arthritis; Medicine; Placebo; Double blind; Post-hoc analysis; Arthritis; Internal medicine; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003088218,0.001989079,0.005867699,0.0006507644,0.0006648844,0.001119613,0.001001911,0.001559859,0.004969842],"category_scores_gemma":[0.001976319,0.0008227085,0.003526541,0.0006551273,0.001517337,0.001295461,0.0004423637,0.002811492,0.0008722637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005616206,"about_ca_system_score_gemma":0.001273587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006996528,"about_ca_topic_score_gemma":0.001433325,"domain_scores_codex":[0.9983814,0.0009525352,0.0001368318,0.0001913786,0.0001038683,0.0002339369],"domain_scores_gemma":[0.9980862,0.0007333428,0.0003189906,0.0002154164,0.0001744011,0.0004715985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9832482,0.004640136,0.0003959675,0.0002395331,0.0009854827,0.00001956566,0.00002353004,0.0001568503,0.003571951,0.00002310534,0.0001175715,0.006578095],"study_design_scores_gemma":[0.7858441,0.2056259,0.004706524,0.00002131106,0.001676176,0.00002829262,0.00003457695,0.0004157368,0.001242445,0.00007168017,0.000305393,0.00002771974],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937636,0.002657506,0.0005423615,0.0001856317,0.0002513206,0.001340128,0.0004927955,0.00008653518,0.000680179],"genre_scores_gemma":[0.9943525,0.001491568,0.0009171312,0.0002867198,0.0003207057,0.001081423,0.0005104555,0.00002738744,0.001012144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005867699,"threshold_uncertainty_score":0.01662576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08820157614001951,"score_gpt":0.421761978181817,"score_spread":0.3335604020417975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}