{"id":"W4401231822","doi":"10.1136/annrheumdis-2024-eular.25","title":"AB0472 EFFICACY OF GUSELKUMAB IN BIONAIVE PSORIATIC ARTHRITIS PATIENTS WITH SEVERE DISEASE ACTIVITY: POST-HOC ANALYSIS OF A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Psoriatic arthritis; Medicine; Placebo; Double blind; Post-hoc analysis; Arthritis; Internal medicine; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00141298,0.0003384292,0.001747012,0.0007560538,0.0001224439,0.00002949455,0.0003555734,0.0001277561,0.0003182574],"category_scores_gemma":[0.0008135264,0.0002247431,0.0008975837,0.001513027,0.0003260744,0.0002656309,0.0001002949,0.0003587728,0.000006680477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003697015,"about_ca_system_score_gemma":0.0003075626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002306408,"about_ca_topic_score_gemma":0.0001407774,"domain_scores_codex":[0.9956336,0.002027269,0.001084617,0.0003835419,0.0005555514,0.000315416],"domain_scores_gemma":[0.9953325,0.00289575,0.0007647623,0.0004608208,0.0003335001,0.0002127154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9105483,0.01400507,0.004164175,0.0007054379,0.014503,0.00001190425,0.002766732,0.005798344,0.00004072866,0.0001865485,0.00004600302,0.04722381],"study_design_scores_gemma":[0.9399951,0.001412596,0.01733392,0.001239327,0.01623075,8.801869e-7,0.0004724011,0.02109006,0.001020313,0.0007660587,0.00001824965,0.0004203656],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901721,0.001822763,0.00003402821,0.0004188808,0.0003452559,0.00622853,0.0008747029,0.00003983906,0.00006383634],"genre_scores_gemma":[0.9986425,0.0005239603,0.000007425312,0.00008491245,0.00001969325,0.0005970357,0.00005951668,0.00002557052,0.00003940666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04680344,"threshold_uncertainty_score":0.9164757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08820157614001951,"score_gpt":0.421761978181817,"score_spread":0.3335604020417975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}