{"id":"W4401232426","doi":"10.1136/annrheumdis-2024-eular.1873","title":"AB0459 BASELINE (BL) DEMOGRAPHICS AND DISEASE CHARACTERISTICS BY MENOPAUSAL STATUS AND SEX IN PATIENTS FROM A PHASE 2 TRIAL OF DEUCRAVACITINIB, A FIRST-IN-CLASS, ORAL, SELECTIVE, ALLOSTERIC TYROSINE KINASE 2 INHIBITOR, IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS (PsA)","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Microscopic Colitis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"","keywords":"Demographics; Internal medicine; Medicine; Disease; Kinase; Class (philosophy); Allosteric regulation; Pharmacology; Oncology; Biology; Genetics; Computer science; Demography; Receptor; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001728979,0.0003129268,0.0008264593,0.000296528,0.00003832188,0.00004184571,0.00009652729,0.00006952774,0.00003586831],"category_scores_gemma":[0.001292428,0.0002456968,0.00005966982,0.0005989711,0.0002405327,0.0002096399,0.0001105931,0.0001943015,4.259772e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006247718,"about_ca_system_score_gemma":0.0003155166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006228422,"about_ca_topic_score_gemma":0.0003522521,"domain_scores_codex":[0.9976023,0.0002412385,0.0008597575,0.0004368776,0.0004823409,0.0003774389],"domain_scores_gemma":[0.998408,0.0004816236,0.0002914554,0.0003234976,0.0001475558,0.0003478981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04522066,0.009019786,0.8337072,0.002059023,0.0003141651,0.0000392757,0.001220247,0.000001630995,0.00004102968,0.00001378731,0.0009892487,0.107374],"study_design_scores_gemma":[0.06355323,0.00304449,0.9237615,0.007831409,0.0002773787,3.517341e-7,0.0000801306,0.0007035694,0.0001223125,0.0002938296,0.00007740752,0.0002544179],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893225,0.002427211,0.000004950622,0.0003145469,0.0001372957,0.001919233,0.005854351,0.00001650796,0.000003398849],"genre_scores_gemma":[0.997021,0.002015323,0.00004251917,0.0001318435,0.00002017066,0.00009638567,0.0006269572,0.00003806868,0.000007705237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1071195,"threshold_uncertainty_score":0.9999995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107916210022197,"score_gpt":0.2683150582866748,"score_spread":0.2575234372844551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}