{"id":"W4401234952","doi":"10.1093/pnasnexus/pgae316","title":"Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights","year":2024,"lang":"en","type":"article","venue":"PNAS Nexus","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Natural Sciences and Engineering Research Council of Canada","funders":"National Institute of Dental and Craniofacial Research; Basic Energy Sciences; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Energy; McGill University; National Institute of General Medical Sciences; Alzheimer's Association; Office of Science; Howard Hughes Medical Institute","keywords":"Regulator; Secretion; Virulence; Cell biology; Biology; Type three secretion system; Computational biology; Response regulator; Bacterial protein; Genetics; Bacteria; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257265,0.0003238626,0.0002740489,0.0001193712,0.0001388197,0.0004028422,0.000313865,0.0005458817,0.0007643776],"category_scores_gemma":[0.00009079053,0.00008235443,0.0003490903,0.00009448459,0.000361491,0.0008344861,0.0002315281,0.0006580317,0.0002855141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002759816,"about_ca_system_score_gemma":0.0002926462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421302,"about_ca_topic_score_gemma":0.0002032069,"domain_scores_codex":[0.9999496,0.000008051092,0.000003338945,0.00001043048,0.00001298918,0.00001562512],"domain_scores_gemma":[0.9999501,0.000008293721,0.00001432088,0.000004870121,0.000008111772,0.00001435351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001218138,0.0000568343,0.0007769364,0.0002399014,0.00001285316,0.0004208414,0.00005833821,0.001173355,0.9881094,0.00369952,0.0001735506,0.00515672],"study_design_scores_gemma":[0.00006373724,0.0008900518,0.01385121,0.00009700914,0.0001037833,0.002416438,0.000791929,0.04611442,0.8884124,0.01109898,0.03610704,0.00005294141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593376,0.01508291,0.02102179,0.001955586,0.0001044024,0.00002714343,0.0002353027,0.0001605226,0.002074738],"genre_scores_gemma":[0.981462,0.007872615,0.008801434,0.0002139463,0.00007500224,0.00001158777,0.0002490753,0.00001165215,0.001302716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007643776,"threshold_uncertainty_score":0.002557099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009346503910848946,"score_gpt":0.2433118885629159,"score_spread":0.2339653846520669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}