{"id":"W4401241395","doi":"10.1002/alz.13921","title":"Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"Genentech","keywords":"TREM2; Microglia; Agonist; Cerebrospinal fluid; Receptor; Medicine; Pharmacology; Biology; Neuroscience; Immunology; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003574939,0.0006281254,0.000284127,0.0005645219,0.000334718,0.0004699778,0.0002407939,0.0003664315,0.002601839],"category_scores_gemma":[0.0003026651,0.0001605556,0.0002180671,0.0002874087,0.000423932,0.0001989756,0.0003087443,0.000622793,0.0006624019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003761368,"about_ca_system_score_gemma":0.0004373019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008760514,"about_ca_topic_score_gemma":0.001522927,"domain_scores_codex":[0.9996941,0.00005471334,0.00001857706,0.00008026472,0.0001076729,0.00004466267],"domain_scores_gemma":[0.9998395,0.00001755239,0.00006115417,0.00001452677,0.00002960301,0.00003766033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004971249,0.00004786999,0.002408986,0.0001049883,0.00002372581,0.0002016979,0.0000417488,0.0000717687,0.9925357,0.00008639201,0.0002225708,0.003757283],"study_design_scores_gemma":[0.00004016871,0.001295956,0.04004638,0.00003808898,0.00006811341,0.002918063,0.0001710468,0.001007941,0.949828,0.0003603861,0.004206385,0.00001952461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769282,0.005363459,0.009075363,0.0002813157,0.00006916327,0.0001947331,0.003413629,0.0002827914,0.004391452],"genre_scores_gemma":[0.9825832,0.001840179,0.00915077,0.0003336426,0.00004187986,0.0003068998,0.003038124,0.00004402369,0.002661239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002601839,"threshold_uncertainty_score":0.008704007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04933052313197055,"score_gpt":0.3114496983019965,"score_spread":0.262119175170026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}