{"id":"W4401252084","doi":"10.3390/pharmaceutics16081030","title":"Next-Generation Contraceptive Intravaginal Ring: Comparison of Etonogestrel and Ethinyl Estradiol In Vitro and In Vivo Release from 3D-Printed Intravaginal Ring and NuvaRing","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Sexual function and dysfunction studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Science Foundation Graduate Research Fellowship Program; National Institute of Allergy and Infectious Diseases; Partenariat Canadien Contre Le Cancer","keywords":"Etonogestrel; Vaginal ring; Population; Medicine; Norethisterone; Intravaginal administration; In vivo; Levonorgestrel; Pharmacology; Chemistry; Vagina; Biology; Surgery; Family planning; Health services; Research methodology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002415723,0.0001871057,0.0003828202,0.0002453388,0.00005400466,0.00006193319,0.00002554882,0.00009091981,0.00003572427],"category_scores_gemma":[0.0001022465,0.0001837761,0.00001252305,0.0001938126,0.0001578649,0.000167179,0.00005228352,0.0006100217,0.00000164584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007778606,"about_ca_system_score_gemma":0.00004835688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003313817,"about_ca_topic_score_gemma":0.00007621157,"domain_scores_codex":[0.9988177,0.00006755206,0.0004032895,0.0003581604,0.0001623795,0.0001909449],"domain_scores_gemma":[0.9994174,0.0002478034,0.00005997947,0.00008396833,0.00005335478,0.000137555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001048954,0.0001623343,0.101386,0.000278304,0.0001566453,0.00006128925,0.007027787,0.0001868077,0.8301173,0.0002341272,0.00007196912,0.05926839],"study_design_scores_gemma":[0.005726822,0.000316448,0.1194255,0.0005412715,0.0004188712,0.0001229734,0.00544439,0.6187983,0.2439008,0.00008030279,0.004841536,0.0003828245],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877178,0.009447908,0.001245753,0.0006485555,0.0003308468,0.0002656733,0.00001566798,0.00005278873,0.0002750073],"genre_scores_gemma":[0.9966168,0.001940185,0.0009686596,0.0002147748,0.0001702554,0.00001310245,0.000014296,0.0000174182,0.00004448152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6186115,"threshold_uncertainty_score":0.749417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1292113428314444,"score_gpt":0.384222490181418,"score_spread":0.2550111473499737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}