{"id":"W4401256296","doi":"10.1101/2024.08.01.605916","title":"Chronic contractile activity induced skeletal muscle-derived extracellular vesicles increase mitochondrial biogenesis in recipient myocytes via transmembrane or peripheral membrane proteins","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba; Research Manitoba","funders":"","keywords":"Myocyte; Skeletal muscle; Transmembrane protein; Cell biology; Mitochondrial biogenesis; Biogenesis; Extracellular; Mitochondrion; Peripheral; Extracellular vesicles; Chemistry; Biophysics; Biology; Internal medicine; Biochemistry; Endocrinology; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001996691,0.0001784383,0.0002982421,0.000120286,0.0001008123,0.0002370227,0.0001126222,0.0002062391,0.001061543],"category_scores_gemma":[0.0001222641,0.00007990988,0.0002826063,0.0001057411,0.0001466293,0.0002176413,0.0002565315,0.0004444507,0.0002157794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001283889,"about_ca_system_score_gemma":0.00008533723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233682,"about_ca_topic_score_gemma":0.0004631225,"domain_scores_codex":[0.9998569,0.00002447442,0.00001930783,0.00003499259,0.00002600719,0.00003830648],"domain_scores_gemma":[0.99989,0.00002490988,0.00002490888,0.00001336039,0.00001721882,0.00002972703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001699962,0.00001921303,0.0001967762,0.00002543865,0.000003560629,0.00002326263,0.000009870396,0.000008881005,0.9991601,0.0000161425,0.00001220492,0.0003547147],"study_design_scores_gemma":[0.00003211012,0.001623313,0.03545868,0.00001834583,0.00003047408,0.000196305,0.000117145,0.0006616896,0.9605439,0.00004654544,0.001266242,0.000005176506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976475,0.0007097581,0.0008756318,0.00003716246,0.00002046339,0.00001783195,0.0002418892,0.00001458692,0.0004351081],"genre_scores_gemma":[0.9968805,0.0003958628,0.0008909828,0.00004684209,0.00001216724,0.00006229067,0.0004955007,0.00001076598,0.001205182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061543,"threshold_uncertainty_score":0.003551185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122868286069697,"score_gpt":0.2286322276215404,"score_spread":0.2174035447608434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}