{"id":"W4401259467","doi":"10.1002/etc.5964","title":"A Quantitative Adverse Outcome Pathway for Embryonic Activation of the Aryl Hydrocarbon Receptor of Fishes by Polycyclic Aromatic Hydrocarbons Leading to Decreased Fecundity at Adulthood","year":2024,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, Davis; Oregon State University; Louisiana State University","keywords":"Aryl hydrocarbon receptor; Vitellogenin; Zebrafish; Fluoranthene; Biology; Estrogen receptor; Fecundity; Toxicity; Developmental toxicity; Pyrene; Internal medicine; Polycyclic aromatic hydrocarbon; Endocrinology; Zoology; Chemistry; Environmental chemistry; Biochemistry; Genetics; Transcription factor; Medicine; Fetus; Gene; Population","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539018,0.0008065155,0.0002787705,0.000511506,0.0002227561,0.0004822187,0.0004353261,0.0003114993,0.001263681],"category_scores_gemma":[0.0008775774,0.0002100244,0.0008356288,0.0001988365,0.0003661512,0.0004430506,0.0007131957,0.0009472864,0.0001873469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009913821,"about_ca_system_score_gemma":0.0007270859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001979254,"about_ca_topic_score_gemma":0.002283234,"domain_scores_codex":[0.9995851,0.00007869901,0.00003535807,0.0001094497,0.0001517807,0.00003955903],"domain_scores_gemma":[0.9991049,0.0002364259,0.0003480747,0.00007663763,0.0001854487,0.00004855438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005148862,0.0002635999,0.03031499,0.0005229551,0.0001439714,0.0004213555,0.00008710691,0.02733254,0.8942196,0.009585244,0.000668323,0.03592547],"study_design_scores_gemma":[0.00008386555,0.003309493,0.1689193,0.00005392422,0.0002561537,0.001505104,0.0001681795,0.1132342,0.692673,0.01084453,0.008777692,0.0001746548],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7014686,0.00173714,0.2838006,0.0003937211,0.00007833257,0.0007519141,0.003896117,0.0006163364,0.007257209],"genre_scores_gemma":[0.9717173,0.0006472405,0.02284126,0.0000948762,0.000009379854,0.0002500041,0.00100648,0.00002153714,0.00341184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001979254,"threshold_uncertainty_score":0.007193089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00885658993113158,"score_gpt":0.2841774377277977,"score_spread":0.2753208477966661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}