{"id":"W4401272581","doi":"10.1002/glia.24598","title":"Early nuclear phenotypes and reactive transformation in human <scp>iPSC</scp>‐derived astrocytes from <scp>ALS</scp> patients with <scp><i>SOD1</i></scp> mutations","year":2024,"lang":"en","type":"article","venue":"Glia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University; Montreal Neurological Institute and Hospital","funders":"Canada First Research Excellence Fund; ALS Society of Canada","keywords":"SOD1; Biology; Astrocyte; Amyotrophic lateral sclerosis; Phenotype; Induced pluripotent stem cell; Astrogliosis; Cell biology; Superoxide dismutase; Oxidative stress; Neurodegeneration; Mutation; Genetics; Gene; Neuroscience; Pathology; Biochemistry; Disease; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000237835,0.0004238733,0.0005435235,0.0004049299,0.0002714209,0.0002955154,0.0002166035,0.0002679517,0.00004684434],"category_scores_gemma":[0.0004399262,0.0003502808,0.0001086133,0.0006473535,0.0002838831,0.0009390746,0.00008701733,0.0008412816,0.0002508111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002851586,"about_ca_system_score_gemma":0.0001267944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009877749,"about_ca_topic_score_gemma":0.0001785332,"domain_scores_codex":[0.9969083,0.0001656573,0.0005531788,0.0007070678,0.000900318,0.0007654832],"domain_scores_gemma":[0.9981272,0.000724897,0.0001314524,0.0003683129,0.000271908,0.0003762457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003042174,0.002227675,0.1992247,0.001335767,0.002190721,0.0004698623,0.2156462,0.00025761,0.5439897,0.002459445,0.01269737,0.01919677],"study_design_scores_gemma":[0.004050366,0.001169138,0.9742007,0.0007244005,0.0002028312,0.000006967986,0.003641554,0.0008724983,0.009221146,0.0006209283,0.005215373,0.00007407327],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938333,0.0003872144,0.0001261092,0.0001854863,0.0001230503,0.001180556,0.0002128116,0.0002516572,0.003699784],"genre_scores_gemma":[0.9973121,0.00008905435,0.0007821036,0.0001456387,0.0001913862,0.00009829341,0.0005281362,0.0001154172,0.0007378954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7749761,"threshold_uncertainty_score":0.9998949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171174573709251,"score_gpt":0.2469026908549183,"score_spread":0.2351909451178258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}