{"id":"W4401272581","doi":"10.1002/glia.24598","title":"Early nuclear phenotypes and reactive transformation in human <scp>iPSC</scp>‐derived astrocytes from <scp>ALS</scp> patients with <scp><i>SOD1</i></scp> mutations","year":2024,"lang":"en","type":"article","venue":"Glia","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University; Montreal Neurological Institute and Hospital","funders":"Canada First Research Excellence Fund; ALS Society of Canada","keywords":"SOD1; Biology; Astrocyte; Amyotrophic lateral sclerosis; Phenotype; Induced pluripotent stem cell; Astrogliosis; Cell biology; Superoxide dismutase; Oxidative stress; Neurodegeneration; Mutation; Genetics; Gene; Neuroscience; Pathology; Biochemistry; Disease; Central nervous system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001558084,0.0002969424,0.0001663976,0.0001611389,0.0001505663,0.0002426561,0.0001416386,0.0002769291,0.0008142529],"category_scores_gemma":[0.0001267373,0.0001191671,0.0002386202,0.00011745,0.0002252356,0.000125507,0.0002481804,0.0004646794,0.0004767294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001026298,"about_ca_system_score_gemma":0.0001270023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004587688,"about_ca_topic_score_gemma":0.0006590101,"domain_scores_codex":[0.9998264,0.00002343818,0.00002633401,0.00003348749,0.00007129908,0.00001911453],"domain_scores_gemma":[0.999874,0.00001940408,0.00003482102,0.00002539952,0.00002048832,0.00002586015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005773278,0.00002054495,0.0002929112,0.00001554106,0.000004151415,0.0002257979,0.00005199045,0.00005280314,0.9984297,0.0001257887,0.00001738048,0.0007056418],"study_design_scores_gemma":[0.00001579681,0.0002489637,0.007546396,0.00000635429,0.0000197344,0.0014966,0.00006292074,0.0006296081,0.9877625,0.0001014794,0.002104395,0.000005241717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886258,0.0004272767,0.007447671,0.0000543569,0.00002885984,0.00004467343,0.0005676073,0.0001059082,0.002697846],"genre_scores_gemma":[0.9937265,0.0003728434,0.002657921,0.00003442178,0.000004881501,0.00005806545,0.001028664,0.0000311507,0.002085572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008142529,"threshold_uncertainty_score":0.002723992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171174573709251,"score_gpt":0.2469026908549183,"score_spread":0.2351909451178258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}