{"id":"W4401273236","doi":"10.1186/s12943-024-02060-5","title":"Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Cisplatin; Lung cancer; Oncology; Drug; microRNA; In vivo; Medicine; Pharmacology; Pembrolizumab; Cancer; Internal medicine; Cancer research; Immunotherapy; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000357267,0.0004380663,0.0004900636,0.0002207593,0.0002021487,0.0004810193,0.0005976759,0.0006987759,0.002078723],"category_scores_gemma":[0.001346476,0.0002039716,0.0007936436,0.0001954083,0.0003484546,0.0005165024,0.0002993354,0.0004879613,0.0002329394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008807174,"about_ca_system_score_gemma":0.0008944648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004500776,"about_ca_topic_score_gemma":0.002379845,"domain_scores_codex":[0.9998704,0.00003827023,0.000007099028,0.00002926246,0.00003643116,0.0000184096],"domain_scores_gemma":[0.9995068,0.0003007738,0.00008220902,0.00002909912,0.00005435726,0.00002674814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002106072,0.0001905132,0.003306596,0.0003372848,0.0000840908,0.000246792,0.00003171401,0.9513611,0.02493234,0.008847782,0.0008896344,0.00956163],"study_design_scores_gemma":[0.00005922689,0.000228677,0.00158715,0.0000177787,0.00006860239,0.00006647778,0.0000230744,0.9866939,0.005777622,0.00351544,0.001947378,0.00001465412],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8690481,0.005361499,0.08894958,0.003367514,0.0003075767,0.0001568823,0.00117474,0.0003889471,0.03124517],"genre_scores_gemma":[0.9939445,0.0009511583,0.00405706,0.0001259257,0.00001866886,0.00005506951,0.0002418868,0.00001998724,0.0005857358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004500776,"threshold_uncertainty_score":0.008949161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124360326168308,"score_gpt":0.2968971616718426,"score_spread":0.2856535584101595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}