{"id":"W4401273236","doi":"10.1186/s12943-024-02060-5","title":"Translational modeling-based evidence for enhanced efficacy of standard-of-care drugs in combination with anti-microRNA-155 in non-small-cell lung cancer","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; National Institutes of Health","keywords":"Cisplatin; Lung cancer; Oncology; Drug; microRNA; In vivo; Medicine; Pharmacology; Pembrolizumab; Cancer; Internal medicine; Cancer research; Immunotherapy; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133988,0.0001635778,0.0002199345,0.0001435892,0.00001703308,0.00001372149,0.0001272223,0.0001194639,0.0000119011],"category_scores_gemma":[0.00001819335,0.0001659857,0.0001101012,0.0002647513,0.00004432951,0.00001119899,0.00001626397,0.00007416173,1.249915e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001278435,"about_ca_system_score_gemma":0.0008365418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113652,"about_ca_topic_score_gemma":0.0003526142,"domain_scores_codex":[0.9988611,0.00004162077,0.0003226893,0.0003934552,0.0001980607,0.0001830776],"domain_scores_gemma":[0.9993934,0.00002824191,0.00009071058,0.0001984034,0.0002553831,0.00003383221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007296095,0.0000510527,0.001621598,0.001064761,0.00003482817,0.000001812067,0.0003282925,0.2757527,0.7192304,0.00002143581,0.00001020891,0.001153235],"study_design_scores_gemma":[0.002654106,0.000153117,0.001923423,0.001555119,0.00007350873,1.996326e-7,0.00003597635,0.09391578,0.8994426,0.00001714613,0.00004180042,0.0001872646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.838403,0.021402,0.1390838,0.0001183711,0.00006273412,0.0007828895,0.0001259578,0.000006013073,0.00001520822],"genre_scores_gemma":[0.9979041,0.0002064721,0.001368856,0.000029765,0.00002523212,0.0002529196,0.000165763,0.00003855195,0.000008350675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1818369,"threshold_uncertainty_score":0.67687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124360326168308,"score_gpt":0.2968971616718426,"score_spread":0.2856535584101595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}