{"id":"W4401273533","doi":"10.1096/fj.202401251r","title":"A novel mechanism of ferroptosis inhibition‐enhanced atherosclerotic plaque stability: YAP1 suppresses vascular smooth muscle cell ferroptosis through GLS1","year":2024,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Science Foundation of Hunan Province","keywords":"YAP1; Vascular smooth muscle; Cell biology; Cancer research; Chemistry; Apolipoprotein E; Cell; Programmed cell death; Biology; Apoptosis; Medicine; Internal medicine; Biochemistry; Endocrinology; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008746544,0.000441138,0.000725801,0.000173163,0.0003682351,0.000203388,0.0003422526,0.0002018629,0.001858513],"category_scores_gemma":[0.00007864643,0.0002937032,0.0007447132,0.000685459,0.0002647142,0.0004012591,0.0001491433,0.0009217192,0.00005508609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002833336,"about_ca_system_score_gemma":0.000418916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001626455,"about_ca_topic_score_gemma":0.00001780269,"domain_scores_codex":[0.9967641,0.0001971761,0.0008645914,0.0005325251,0.001013912,0.0006277376],"domain_scores_gemma":[0.9982163,0.0001985592,0.0002675485,0.0007210297,0.0003457009,0.0002508588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001496872,0.0006377645,0.00009158995,0.0006419521,0.0003219219,0.00001728662,0.003485908,0.00007261959,0.9916753,0.0008762514,0.000540175,0.001489514],"study_design_scores_gemma":[0.001901114,0.000709801,0.001022836,0.001355964,0.0009290902,0.00007898271,0.002425034,0.0004816258,0.9884112,0.001325958,0.001023581,0.0003347496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604704,0.002395306,0.03150941,0.002620091,0.0006711975,0.0007516738,0.0001158012,0.0001394078,0.001326701],"genre_scores_gemma":[0.9940889,0.002335023,0.002294071,0.0005199128,0.0004184041,0.000098432,0.00001736455,0.0001096532,0.0001181934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03361854,"threshold_uncertainty_score":0.9999515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.033506137431966,"score_gpt":0.258979151700212,"score_spread":0.225473014268246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}