{"id":"W4401277937","doi":"10.1080/21645515.2024.2374147","title":"Immunogenicity and safety of an <i>Entamoeba histolytica</i> adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques","year":2024,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Immunogenicity; Adjuvant; Entamoeba histolytica; Avidity; Immunization; Immunology; Antigen; Immune system; Antibody; Virology; Biology; Peripheral blood mononuclear cell; Microbiology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002747233,0.0002440205,0.0001697576,0.0001114763,0.0001232362,0.0002755115,0.0001423585,0.0003530377,0.0004670722],"category_scores_gemma":[0.0003156039,0.00008575636,0.0001628033,0.00005342842,0.0002144761,0.0002122914,0.0001103479,0.0004141189,0.0001812806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483799,"about_ca_system_score_gemma":0.0002069181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170788,"about_ca_topic_score_gemma":0.000765316,"domain_scores_codex":[0.9998568,0.0000336917,0.00001205453,0.00002940369,0.00003250415,0.00003543892],"domain_scores_gemma":[0.9998804,0.0000204627,0.00003395775,0.00001302814,0.00003080357,0.0000213469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001643749,0.0004974548,0.001315847,0.00007503231,0.00001990532,0.00006804064,0.00006753433,0.0001886832,0.992347,0.00006901175,0.00009401239,0.0036138],"study_design_scores_gemma":[0.0002656577,0.04342312,0.02749576,0.00004290746,0.0001544068,0.0006367664,0.0001855103,0.002697428,0.9204409,0.0001173499,0.004520699,0.00001957529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991894,0.0002648683,0.0002302313,0.00003430922,0.0000107182,0.00001921228,0.00004172261,0.000007875566,0.0002016005],"genre_scores_gemma":[0.9989107,0.0001933851,0.0002201844,0.000053572,0.00001010086,0.0000281746,0.0001307026,0.000003547093,0.000449613],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001170788,"threshold_uncertainty_score":0.002327979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138540984379233,"score_gpt":0.2913056655705974,"score_spread":0.2799202557268051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}