{"id":"W4401285048","doi":"10.1021/acs.jmedchem.4c00688","title":"Expanding Structure–Activity Relationships of Human Urotensin II Peptide Analogues: A Proposed Key Role of the N-Terminal Region for Novel Urotensin II Receptor Modulators","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Regione Campania","keywords":"Urotensin-II; Chemistry; Peptide; Key (lock); Receptor; Terminal (telecommunication); Biochemistry; Biology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111913,0.0002048834,0.000183975,0.00007556064,0.00005060421,0.0001644247,0.000134471,0.000161098,0.001182063],"category_scores_gemma":[0.0001182441,0.00005673344,0.0001462732,0.00008622237,0.00008992862,0.0001371512,0.00009838945,0.0003193823,0.0001938256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139579,"about_ca_system_score_gemma":0.00008910659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001661178,"about_ca_topic_score_gemma":0.0003485948,"domain_scores_codex":[0.9999647,0.00000835122,0.000003679058,0.000006878606,0.000008291194,0.000007995936],"domain_scores_gemma":[0.9999609,0.000008054408,0.00001049704,0.000002933629,0.000006505519,0.00001108685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002574184,0.00006324454,0.0002650263,0.00006763087,0.00001053976,0.00009232362,0.000014813,0.0004831686,0.9940765,0.0001059526,0.00004585718,0.004517622],"study_design_scores_gemma":[0.0001119843,0.006609016,0.00436099,0.00001740972,0.0000842907,0.0005840387,0.00003865699,0.002332926,0.9787756,0.0001115116,0.006957314,0.00001628386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923251,0.003901202,0.002055007,0.00007593783,0.00003014839,0.00005833143,0.0001426268,0.00001517474,0.001396518],"genre_scores_gemma":[0.9941275,0.002302526,0.002075799,0.00009069363,0.00001429605,0.00002437153,0.0002766724,0.000003651368,0.001084396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182063,"threshold_uncertainty_score":0.003954351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04096835426432317,"score_gpt":0.3068066579434981,"score_spread":0.2658383036791749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}