{"id":"W4401285260","doi":"10.1038/s41531-024-00761-8","title":"Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease","year":2024,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Avid Radiopharmaceuticals; Allergan; Genentech; H. Lundbeck A/S; Servier; Sun Pharma; Voyager Therapeutics; Neurocrine Biosciences; Weston Brain Institute; LifeArc; Medical Research Council; Biogen; Celgene; Verily Life Sciences; Teva Pharmaceutical Industries; Eli Lilly and Company; Bristol-Myers Squibb; Pfizer; Sanofi; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Interactome; Transcriptome; Parkinson's disease; Disease; Biology; Ribosomal protein; Gene; Genetics; Computational biology; Bioinformatics; Gene expression; Medicine; Internal medicine; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720335,0.0002941865,0.0002693369,0.001076991,0.0002159402,0.0003898266,0.0001499294,0.0002111239,0.001186969],"category_scores_gemma":[0.0005248719,0.0001101834,0.0005149571,0.001027623,0.0001988345,0.000379284,0.0003261508,0.0002220388,0.0001792196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045099,"about_ca_system_score_gemma":0.0001540295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531769,"about_ca_topic_score_gemma":0.002260712,"domain_scores_codex":[0.9998041,0.00003532395,0.00001017343,0.00008382707,0.0000388499,0.0000278021],"domain_scores_gemma":[0.9998181,0.00005033445,0.00007234466,0.00001591797,0.00002434551,0.00001901918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00148988,0.000160921,0.2307275,0.0009240953,0.001356097,0.001276682,0.0006308749,0.05213843,0.6307592,0.005811897,0.001818688,0.0729057],"study_design_scores_gemma":[0.00001635035,0.0002278663,0.8045914,0.00003492977,0.0002843024,0.001110984,0.0003577092,0.1599651,0.01996695,0.009325765,0.004073108,0.00004558413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976608,0.0008072867,0.01758313,0.0001134329,0.00001059624,0.00002125021,0.003567219,0.0001288382,0.001160091],"genre_scores_gemma":[0.9907575,0.0003483264,0.004726553,0.00002353663,0.000008579086,0.00004650123,0.00341904,0.00002066897,0.0006491853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531769,"threshold_uncertainty_score":0.003970802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955613023802208,"score_gpt":0.290242186921884,"score_spread":0.2706860566838619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}