{"id":"W4401286465","doi":"10.1021/acsomega.4c04998","title":"PACS-1 Interacts with TRPC3 and ESyt1 to Mediate Protein Trafficking while Promoting SOCE and Cooperatively Regulating Hormone Secretion","year":2024,"lang":"en","type":"article","venue":"ACS Omega","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research","keywords":"TRPC3; Secretion; Endoplasmic reticulum; Cell biology; STIM1; Adrenocorticotropic hormone; Internal medicine; Endocrinology; Receptor; Chemistry; Biology; Transient receptor potential channel; Hormone; TRPC; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001619666,0.0003105401,0.0002866386,0.0001891773,0.0004681408,0.0004247914,0.0001732176,0.0004197753,0.001697621],"category_scores_gemma":[0.0002702874,0.000107471,0.0004033965,0.0001669001,0.000363961,0.0006388294,0.0004924609,0.0007085898,0.0004670589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000442303,"about_ca_system_score_gemma":0.0003526651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728145,"about_ca_topic_score_gemma":0.0005914127,"domain_scores_codex":[0.9998311,0.00002046493,0.00001206776,0.00003746785,0.00004143376,0.00005748153],"domain_scores_gemma":[0.9998987,0.00001285955,0.00002930836,0.00001066772,0.00001723599,0.00003116196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001310732,0.00001246078,0.0007758063,0.00009082861,0.00001212515,0.0003692615,0.00003956449,0.0001207474,0.9956746,0.0007191294,0.0002645847,0.001789853],"study_design_scores_gemma":[0.00006123153,0.0001734457,0.02174625,0.00002013863,0.00005147034,0.001992447,0.0001859978,0.005587231,0.9582514,0.0009006844,0.01100216,0.00002756281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856914,0.003538518,0.00671926,0.0005695678,0.0001438877,0.00002695429,0.0003631216,0.0001755886,0.002771704],"genre_scores_gemma":[0.9948486,0.000982549,0.00180459,0.0001057476,0.00002518659,0.00002529496,0.0002623553,0.00002101871,0.001924655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001697621,"threshold_uncertainty_score":0.005679131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244166695687661,"score_gpt":0.2521391954467767,"score_spread":0.2296975284899001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}