{"id":"W4401286465","doi":"10.1021/acsomega.4c04998","title":"PACS-1 Interacts with TRPC3 and ESyt1 to Mediate Protein Trafficking while Promoting SOCE and Cooperatively Regulating Hormone Secretion","year":2024,"lang":"en","type":"article","venue":"ACS Omega","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Schulich School of Medicine and Dentistry; Canadian Institutes of Health Research","keywords":"TRPC3; Secretion; Endoplasmic reticulum; Cell biology; STIM1; Adrenocorticotropic hormone; Internal medicine; Endocrinology; Receptor; Chemistry; Biology; Transient receptor potential channel; Hormone; TRPC; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436188,0.0001658279,0.0001547192,0.0001094922,0.0002415131,0.0003285434,0.00006996874,0.00005508208,0.00000388446],"category_scores_gemma":[0.0002524605,0.0001187196,0.00001422191,0.0003808468,0.00008063413,0.0004235576,0.00008368717,0.0001989203,0.000007913147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002810065,"about_ca_system_score_gemma":0.00003364878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008500891,"about_ca_topic_score_gemma":0.00001042039,"domain_scores_codex":[0.9988032,0.00007525276,0.0001775598,0.0004756637,0.0002072847,0.0002610315],"domain_scores_gemma":[0.9995983,0.0001223668,0.00005174392,0.00006560577,0.0000381394,0.0001238654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003541079,0.00001645084,0.00001122436,0.0000810967,0.000005446757,0.00002252724,0.01301193,0.00005847119,0.9728548,0.0003091809,0.00008559279,0.01350789],"study_design_scores_gemma":[0.0004106569,0.0006153883,0.0002296404,0.0008763784,0.00001217853,0.00009449884,0.0008243268,0.01270113,0.9826482,0.00006905958,0.001197272,0.0003213003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997049,0.0002090148,0.0001700919,0.001454052,0.0001398842,0.0005523899,0.000006628097,0.0001421797,0.0002767094],"genre_scores_gemma":[0.9988565,0.00003277032,0.0002666261,0.000129936,0.0001587141,0.0000478278,0.000002837706,0.00003242378,0.000472325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01318659,"threshold_uncertainty_score":0.4841245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02244166695687661,"score_gpt":0.2521391954467767,"score_spread":0.2296975284899001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}