{"id":"W4401288386","doi":"10.1093/noajnl/vdae090.114","title":"RMTD-07 LOST CHANCES: THE SYSTEMATIC EXCLUSION OF PATIENTS WITH BRAIN METASTASIS IN EARLY-PHASE ONCOLOGY TRIALS","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Clinical trial; Internal medicine; Chemotherapy; Oncology; Immunotherapy; Lung cancer; Brain metastasis; Cancer; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.297887,0.001882794,0.006542637,0.01006254,0.001106093,0.006636116,0.003372533,0.003662593,0.008656822],"category_scores_gemma":[0.4873392,0.00167121,0.006992317,0.01054584,0.003200852,0.005547254,0.004581289,0.003527898,0.002514785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003460285,"about_ca_system_score_gemma":0.009875999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252949,"about_ca_topic_score_gemma":0.003208672,"domain_scores_codex":[0.4884193,0.361472,0.1094042,0.01221406,0.02674018,0.001750315],"domain_scores_gemma":[0.3732063,0.4814703,0.08613023,0.02492347,0.029775,0.004494795],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"observational","study_design_scores_codex":[0.02800408,0.0002732701,0.04354657,0.5016886,0.04055306,0.001073075,0.002237459,0.001548622,0.001752735,0.008859159,0.08088682,0.2895766],"study_design_scores_gemma":[0.03987579,0.003427782,0.06571946,0.463492,0.05077376,0.002623624,0.0008585549,0.003625739,0.002970283,0.02449127,0.3416898,0.000451974],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05122128,0.6634843,0.04802321,0.04272175,0.009548375,0.1011971,0.05189233,0.0009765388,0.03093508],"genre_scores_gemma":[0.4595748,0.1566532,0.08333295,0.0573087,0.007794649,0.205628,0.02311239,0.0008679937,0.005727257],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.702113,"threshold_uncertainty_score":0.8658304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867300915596553,"score_gpt":0.3767669174631672,"score_spread":0.3380939083072017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}