{"id":"W4401295978","doi":"10.1093/noajnl/vdae090.132","title":"TRSC-04 DE NOVO GTP SYNTHESIS IS A METABOLIC VULNERABILITY FOR THE INTERCEPTION OF BRAIN METASTASES","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"In vivo; GTP'; Cancer research; De novo synthesis; Druggability; Biology; Pharmacology; Chemistry; Enzyme; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009302166,0.0001681056,0.0002780203,0.0000848899,0.0001272192,0.00002045086,0.000310497,0.0001559437,0.0001035845],"category_scores_gemma":[0.002395024,0.000123557,0.0002396629,0.0001820436,0.0004552619,0.00001457746,0.0001078649,0.0002150496,0.000009500924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004327003,"about_ca_system_score_gemma":0.0002530254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001865756,"about_ca_topic_score_gemma":0.0001544227,"domain_scores_codex":[0.9983001,0.0004459265,0.0003068856,0.0004808311,0.0001480804,0.0003181587],"domain_scores_gemma":[0.9976268,0.00172829,0.00007636143,0.000390516,0.0001143026,0.00006369464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000269325,0.00008937999,0.0001342296,0.0001059848,0.00009845824,0.000007201267,0.000180045,0.00009323925,0.9177135,0.000140969,0.007436553,0.0737311],"study_design_scores_gemma":[0.0001523935,0.000284105,0.00008471085,0.00001017966,0.00005659877,0.00003735924,0.0001294841,0.0002033205,0.5477914,0.0001175406,0.4510624,0.00007047499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668491,0.01628034,0.009913043,0.005061589,0.0005826326,0.0006307603,0.0003253522,0.00003517406,0.0003220087],"genre_scores_gemma":[0.9952005,0.001501188,0.001273363,0.0008513217,0.0003717073,0.0005141827,0.0000212708,0.00003277709,0.0002336788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4436259,"threshold_uncertainty_score":0.5038509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02142897663476155,"score_gpt":0.3653325293651381,"score_spread":0.3439035527303765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}