{"id":"W4401318023","doi":"10.1016/j.jconrel.2024.07.078","title":"Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity","year":2024,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC; NanoMedicines Innovation Network; Canadian Institutes of Health Research; Social Sciences and Humanities Research Council of Canada; Clinical Trials Fund, Canadian Institutes of Health Research","keywords":"Reactogenicity; Biodistribution; Gene knockdown; Messenger RNA; RNA; Biology; Pharmacology; Cell biology; Immunogenicity; Immune system; Immunology; Biochemistry; Apoptosis; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005784142,0.0003973517,0.0002248752,0.0001880705,0.0001088229,0.0005084954,0.0001679218,0.0002869485,0.0007373119],"category_scores_gemma":[0.0008952181,0.0002126548,0.0001947431,0.0001287952,0.0003182993,0.0005846084,0.0001945304,0.0004063644,0.0003217082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002160026,"about_ca_system_score_gemma":0.0002946454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790424,"about_ca_topic_score_gemma":0.0006021885,"domain_scores_codex":[0.9996864,0.00006767298,0.0000320939,0.00009384065,0.00005586412,0.00006419235],"domain_scores_gemma":[0.999443,0.00025298,0.0001497605,0.00003095282,0.00008907286,0.00003418964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001090667,0.00002611045,0.0003903529,0.00007033166,0.000005776039,0.00003613851,0.00003245926,0.0001516988,0.9967836,0.00009092285,0.00003089652,0.002272553],"study_design_scores_gemma":[0.000006428522,0.0004006738,0.001935042,0.000009389176,0.00002696659,0.00007422992,0.00004160381,0.001728239,0.9944077,0.00004660627,0.00131435,0.000008899494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877564,0.0022453,0.007712707,0.00009352208,0.00004673213,0.0000758965,0.0001115436,0.00009884233,0.001859034],"genre_scores_gemma":[0.9916331,0.002020852,0.004610316,0.00007415118,0.00001393884,0.00006334187,0.0001132629,0.00005692307,0.001414064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007373119,"threshold_uncertainty_score":0.00305903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008062923880746718,"score_gpt":0.250851972205725,"score_spread":0.2427890483249783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}