{"id":"W4401318023","doi":"10.1016/j.jconrel.2024.07.078","title":"Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity","year":2024,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Michael Smith Health Research BC; NanoMedicines Innovation Network; Canadian Institutes of Health Research; Social Sciences and Humanities Research Council of Canada; Clinical Trials Fund, Canadian Institutes of Health Research","keywords":"Reactogenicity; Biodistribution; Gene knockdown; Messenger RNA; RNA; Biology; Pharmacology; Cell biology; Immunogenicity; Immune system; Immunology; Biochemistry; Apoptosis; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294464,0.000100868,0.000225343,0.00006291176,0.00003804553,0.00005323072,0.00007026071,0.0001020359,0.000004574322],"category_scores_gemma":[0.0001427107,0.00007550642,0.0001009433,0.00004496762,0.00005344782,0.00002104423,0.00003371048,0.0001040923,5.473843e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001040531,"about_ca_system_score_gemma":0.0001212485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006800503,"about_ca_topic_score_gemma":0.000003544114,"domain_scores_codex":[0.9991636,0.00006219222,0.0004189077,0.0001340233,0.0001265788,0.00009475394],"domain_scores_gemma":[0.99931,0.00004600548,0.0002306296,0.00008618737,0.0002392267,0.00008791812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001299671,0.00005200507,0.001684768,0.00004594202,0.0001312453,0.00001994703,0.00004487413,0.00001517903,0.9934992,0.00001641819,0.0003387234,0.002852068],"study_design_scores_gemma":[0.003478157,0.001695675,0.005720637,0.0002671491,0.0002190772,0.0001596192,0.000141817,0.0007599416,0.9848668,0.0001531067,0.002384177,0.0001538156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9853269,0.01351655,0.0006940606,0.0001901092,0.0001137515,0.00009026637,0.0000221455,0.000004440877,0.00004171073],"genre_scores_gemma":[0.9961066,0.003404474,0.0002488678,0.00004823667,0.0001510128,0.000001925907,0.000008816135,0.000005455227,0.00002464155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01077961,"threshold_uncertainty_score":0.3079062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008062923880746718,"score_gpt":0.250851972205725,"score_spread":0.2427890483249783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}