{"id":"W4401325374","doi":"10.1097/mcg.0000000000002056","title":"Real-world Clinical Effectiveness and Safety of Vedolizumab and Adalimumab in Biologic-naive Patients With Crohn’s Disease","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thermo Fisher Scientific (Canada); St. Paul's Hospital","funders":"","keywords":"Vedolizumab; Medicine; Adalimumab; Crohn's disease; Internal medicine; Disease; Monoclonal; Real world data; Monoclonal antibody; Immunology; Antibody; Data science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009401628,0.0002813755,0.001015247,0.0005380956,0.0002864002,0.001176666,0.0003410901,0.0006111172,0.0007434708],"category_scores_gemma":[0.01779259,0.0001918368,0.001356947,0.0005000817,0.0004616298,0.0009501387,0.0004780771,0.0006911199,0.0001300576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008246365,"about_ca_system_score_gemma":0.0004338924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006618986,"about_ca_topic_score_gemma":0.0009877463,"domain_scores_codex":[0.9927603,0.004430347,0.0008573289,0.0007375287,0.001006396,0.0002081064],"domain_scores_gemma":[0.9826115,0.007062411,0.008349034,0.000673177,0.0006493069,0.0006547163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03992496,0.001244768,0.9045719,0.0005293035,0.003761682,0.0001092255,0.0002376822,0.002237642,0.001158456,0.0001367725,0.0003195329,0.04576811],"study_design_scores_gemma":[0.002955675,0.02333012,0.9632785,0.0001577881,0.001661536,0.0006347768,0.000260421,0.004276652,0.001184192,0.0002097354,0.001988272,0.00006227916],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964301,0.002540274,0.0001852989,0.0001017252,0.00001257008,0.00003315266,0.00029356,0.000004688323,0.0003986432],"genre_scores_gemma":[0.9989568,0.0002789691,0.0002369362,0.00006057695,0.00002536594,0.000026121,0.000363204,0.000001426662,0.0000504345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009401628,"threshold_uncertainty_score":0.04972118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140229293443019,"score_gpt":0.3298828769497755,"score_spread":0.3158599476054736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}