{"id":"W4401335574","doi":"10.1038/s41531-024-00744-9","title":"Lack of genetic evidence for NLRP3 inflammasome involvement in Parkinson’s disease pathogenesis","year":2024,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canada First Research Excellence Fund; Parkinson Canada; Consortium canadien en neurodégénérescence associée au vieillissement; Parkinson Study Group; McGill University; Compute Canada; Michael J. Fox Foundation for Parkinson's Research; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Parkinson's disease; Pathogenesis; Inflammasome; Medicine; Disease; Neurology; Neuroscience; Bioinformatics; Psychiatry; Psychology; Immunology; Biology; Internal medicine; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001591163,0.000529592,0.0005912419,0.0009473992,0.0003405614,0.0005785895,0.0004264901,0.0006150142,0.002917575],"category_scores_gemma":[0.003762097,0.0001760688,0.000887429,0.0006761859,0.0008021806,0.000371056,0.0004923891,0.000391669,0.0002329545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201796,"about_ca_system_score_gemma":0.00042016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530118,"about_ca_topic_score_gemma":0.001127964,"domain_scores_codex":[0.9986511,0.0004369034,0.0001865049,0.0004052306,0.0002363458,0.00008396806],"domain_scores_gemma":[0.9978836,0.0009538676,0.0005869385,0.0002972095,0.0001376618,0.000140745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005460561,0.0001938668,0.8654762,0.000580535,0.00236167,0.008212038,0.0005693976,0.0007417837,0.07674284,0.002713328,0.0007278492,0.03621994],"study_design_scores_gemma":[0.0002369744,0.0006626491,0.9649442,0.00017104,0.001200099,0.01585545,0.0002385223,0.001552136,0.00640612,0.005309091,0.003397202,0.00002642474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919749,0.002590475,0.002494327,0.0004388864,0.00004117803,0.00002471979,0.000518008,0.00004115345,0.001876269],"genre_scores_gemma":[0.9984389,0.0004811878,0.0006720189,0.0000737468,0.00001945305,0.000007475717,0.0001518292,0.000007770211,0.0001477186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002917575,"threshold_uncertainty_score":0.00976032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03981761293390616,"score_gpt":0.3060403517301462,"score_spread":0.26622273879624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}