{"id":"W4401345796","doi":"10.3389/fnins.2024.1436262","title":"“Prion-like” seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders","year":2024,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"Krembil Foundation","keywords":"Prion protein; Neuroscience; Seeding; Biology; Chemistry; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452728,0.0002574642,0.000490253,0.0003543519,0.00004219738,0.00005396342,0.0002931958,0.000138067,4.794842e-7],"category_scores_gemma":[0.0001875829,0.0002239808,0.0001075078,0.0007440272,0.000197938,0.00001512343,0.0002426238,0.0002146413,3.881949e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002740668,"about_ca_system_score_gemma":0.0001977898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001092458,"about_ca_topic_score_gemma":0.000009112874,"domain_scores_codex":[0.9983465,0.0001524114,0.0003867632,0.0007087922,0.0001646356,0.0002409053],"domain_scores_gemma":[0.9995317,0.000007058769,0.0001784279,0.0002114511,0.00001599041,0.00005533252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000153977,0.00005254314,0.0004480612,0.006072599,0.000008590358,0.00001076873,0.00005862802,0.00004660646,0.01270647,0.00006423318,0.0003456897,0.9801704],"study_design_scores_gemma":[0.0003971088,0.000492195,0.0003521578,0.008933578,0.0001548082,0.00002134921,0.0001151577,0.002125983,0.001817283,0.0004115212,0.9841662,0.001012637],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004103438,0.9932202,0.001006835,0.00002263568,0.0006709006,0.0009161783,0.00001907652,0.000007758716,0.00003301592],"genre_scores_gemma":[0.007559464,0.9915128,0.0005616962,0.00002481142,0.00004104109,0.0001740361,0.00001526812,0.00002813455,0.0000827985],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9838206,"threshold_uncertainty_score":0.9133673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824812739401781,"score_gpt":0.2990347790938586,"score_spread":0.2807866516998408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}