{"id":"W4401374310","doi":"10.1007/978-1-0716-3995-5_11","title":"A Method for Producing Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Leigh Syndrome Patients for Its Application in Disease Modeling and Drug Validation","year":2024,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Induced pluripotent stem cell; Disease; Drug; Neuroscience; Medicine; Computational biology; Biology; Pharmacology; Internal medicine; Embryonic stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008015637,0.0007136025,0.0003456329,0.0008732878,0.0005097179,0.0003992175,0.0005000662,0.0006867259,0.002085568],"category_scores_gemma":[0.0007118857,0.0003860862,0.0005096992,0.0004569543,0.0003916742,0.0003215009,0.0006386111,0.001263978,0.001261168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001806917,"about_ca_system_score_gemma":0.0005435647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004368299,"about_ca_topic_score_gemma":0.0009937416,"domain_scores_codex":[0.9995485,0.00008664885,0.00006706446,0.00009355546,0.0001692651,0.0000348132],"domain_scores_gemma":[0.99966,0.0001006019,0.00005515026,0.00008889819,0.00006107628,0.00003423685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002693522,0.0000217542,0.000134127,0.0000756764,0.00001036368,0.000193042,0.00003628345,0.0001423839,0.98695,0.0005948729,0.0003918717,0.01142271],"study_design_scores_gemma":[0.00004064428,0.0001961531,0.001332097,0.00003140117,0.00006056153,0.001766551,0.00002884338,0.00151558,0.9755973,0.0004702842,0.01892674,0.00003384702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.06958745,0.002797828,0.9145581,0.0006645322,0.0004277877,0.001334637,0.002196625,0.001511111,0.006921928],"genre_scores_gemma":[0.2860883,0.003960326,0.694183,0.0004736395,0.00008939584,0.002064524,0.004811407,0.0003918684,0.007937505],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002085568,"threshold_uncertainty_score":0.006976902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391507160413342,"score_gpt":0.3390680493534621,"score_spread":0.3151529777493287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}