{"id":"W4401375801","doi":"10.1186/s40168-024-01862-5","title":"Engineering a dysbiotic biofilm model for testing root caries interventions through microbial modulation","year":2024,"lang":"en","type":"article","venue":"Microbiome","topic":"Oral microbiology and periodontitis research","field":"Dentistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Academy of Medical Sciences","keywords":"Biofilm; Sucrose; Biology; Saliva; Microbiology; Microbiome; Microbial ecology; Food science; Root caries; Bacteria; Dental plaque; Microorganism; Biochemistry; Dentistry; Bioinformatics; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005400718,0.0005823372,0.0005831187,0.0002962072,0.0002127094,0.0005993793,0.000452476,0.000646074,0.0009402743],"category_scores_gemma":[0.0002808687,0.000248118,0.0004156273,0.0001713214,0.0003134362,0.0003232571,0.0005838383,0.0006823292,0.000300502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000319245,"about_ca_system_score_gemma":0.0004890078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006290328,"about_ca_topic_score_gemma":0.001459941,"domain_scores_codex":[0.999518,0.00006564582,0.00003484542,0.0001155073,0.0002022709,0.00006375494],"domain_scores_gemma":[0.9997438,0.00004220684,0.00008640416,0.00002522074,0.00006435958,0.00003802735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002476901,0.00002983897,0.0001157925,0.00005435322,0.000002695434,0.00001623956,0.00001005087,0.00005282282,0.9989902,0.00002166678,0.000008714455,0.0006727122],"study_design_scores_gemma":[0.00002023168,0.001639562,0.004427568,0.00002544289,0.00004899656,0.0002584188,0.0001027494,0.001906012,0.9885994,0.0001166821,0.002840091,0.0000148481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819983,0.002240857,0.0141367,0.0001374819,0.00005660564,0.0002249841,0.0003835065,0.0000663101,0.0007552315],"genre_scores_gemma":[0.9572863,0.002451345,0.03775879,0.0001248625,0.00002374136,0.000336284,0.000481815,0.0000354453,0.001501403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009402743,"threshold_uncertainty_score":0.003145516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07999665202494881,"score_gpt":0.3413171693573976,"score_spread":0.2613205173324488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}