{"id":"W4401383708","doi":"10.1002/ange.202405941","title":"Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid‐Free Analgesics","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Neurotensin; Opioid; Pharmacology; Analgesic; Chemistry; Morphine; Medicine; Receptor; Glycine; Stereochemistry; Biochemistry; Neuropeptide; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000889592,0.0003258655,0.0002243411,0.0001433544,0.00009145038,0.0001655094,0.0001984669,0.000188185,0.00196123],"category_scores_gemma":[0.0001005383,0.00008952102,0.0001413851,0.00008924809,0.00009768204,0.0001615125,0.0001934091,0.0002773638,0.0003915228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001689972,"about_ca_system_score_gemma":0.0001566447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003753536,"about_ca_topic_score_gemma":0.001150168,"domain_scores_codex":[0.9999548,0.000007988403,0.000003443944,0.00001122577,0.000009061711,0.00001345634],"domain_scores_gemma":[0.9999604,0.000004599619,0.00001268756,0.000003102982,0.000007567264,0.00001173786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003246388,0.00007981197,0.0001671815,0.0002081024,0.00002512573,0.00016665,0.00002234422,0.001013919,0.9851799,0.0005766741,0.0003229386,0.01191267],"study_design_scores_gemma":[0.0001889682,0.00601925,0.003470402,0.00004412102,0.0000690696,0.0005461961,0.00003306668,0.00246349,0.9591781,0.0002033931,0.02775149,0.00003238243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688306,0.009747817,0.009677357,0.0001922728,0.0001368102,0.0002633408,0.0009243564,0.0001492715,0.01007805],"genre_scores_gemma":[0.9855407,0.004229657,0.005070683,0.0001566142,0.00002542661,0.0001229047,0.0005630506,0.00001494885,0.004275988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00196123,"threshold_uncertainty_score":0.006560981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04514313524990813,"score_gpt":0.2758678138380171,"score_spread":0.2307246785881089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}